Células‐tronco oriundas do fluxo menstrual: possíveis aplicações

Gisela Rodrigues da Silva Sasso, Michele Longoni Calió, Luiz Fernando Portugal Fuchs, Cristiane de Paula Teixeira, Ricardo Santos Simões, Rinaldo Florencio‐Silva
In: Reprodução & Climatério · 2016 · vol. 32(1) , pp. 39–42 · doi:10.1016/j.recli.2016.05.003 · W2490497087
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Menstrual blood-derived stem cells (MenSCs) are non-invasively obtained mesenchymal stem cells with high proliferation and low immunogenicity, showing promise for tissue engineering, repair, and understanding gynecological diseases.

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Abstract

Células‐tronco adultas estão presentes em diversos tecidos, inclusive no endométrio humano, e podem ser obtidas a partir do sangue do fluxo menstrual (MenSCs) de uma forma não invasiva. Devido à sua alta taxa de proliferação, baixa imunogenicidade e baixa tumorigenicidade, essas células podem ser usadas na engenharia de tecidos. Sob determinadas condições de cultura, elas podem ser induzidas a se diferenciar em várias linhagens de células. As MenSCs podem contribuir para a reparação dos tecidos por intermédio de vários mecanismos, destaca‐se sua grande promessa em aplicações clínicas. Além disso, as células‐tronco mesenquimais do endométrio podem ser usadas para o melhor entendimento da patogênese da endometriose e do carcinoma endometrial. Adult stem cells are present in several human tissues, including the endometrium. Menstrual blood derived stem cells (MenSCs) are mesenchymal stem cells that can be obtained in a non‐invasive manner. Due to its rapid proliferation rate, low immunogenicity and low tumorigenicity, MenSCs are used extensively in tissue engineering. They can be induced into multiple cell lineages under certain conditions. MenSCs contribute to tissue repair via several different mechanisms, highlighting their great promise in clinical applications. Endometrial stem cells may also be used to shed light on the pathogenesis of endometriosis and endometrial carcinoma. This review will cover recent progress in this field.

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endometriosis

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