Identification and characterisation of human endometrial stem/progenitor cells
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Researchers identified rare clonogenic epithelial and stromal cells in human endometrium, likely representing stem/progenitor populations, by initiating large clones.
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Abstract
The human endometrium is a dynamic, cyclically regenerating tissue. Because adult stem cells are present in other regenerative tissues, a clonal analysis of purified endometrial epithelial and stromal cells derived from hysterectomy tissue was undertaken, as a first attempt to identify and characterise endometrial stem/progenitor cells. Rare populations of epithelial and stromal cells were clonogenic. Only those cells initiating large clones, 0.09% of epithelial cells and 0.02% of stromal cells, are likely to be endometrial stem/progenitor cells.
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Cited by (29)
- Endometriosis-related alterations in the endometrium revealed by integrated single-cell and AI-powered approaches 2026
- Tracing Endometriosis: Coupling deeply phenotyped, single-cell based Endometrial Differences and AI for disease pathology and prediction 2024
- The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure 2022
- Endometrial stem/progenitor cells: Properties, origins, and functions 2022
- Endometrial stem/progenitor cells in menstrual blood and peritoneal fluid of women with and without endometriosis 2021
- Establishment of endometriotic models: the past and future 2020
- Progesterone Resistance and Adult Stem Cells’ Genomic and Epigenetic Changes in the Puzzle of Endometriosis 2019
- Anti-inflammatory cytokines in endometriosis 2019
- Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions 2018
- Analysis of menstrual effluent: diagnostic potential for endometriosis 2018
- When endometriosis is the barrier for fertility 2017
- Angiogenic properties of endometrial mesenchymal stromal cells in endothelial co-culture: an in vitro model of endometriosis 2017
- Células‐tronco oriundas do fluxo menstrual: possíveis aplicações 2016
- Expression of stem cell-related genes in the endometrium and endometriotic lesions: a pilot study 2015
- Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype 2014
- Identification and characterization of the somatic stem cell niche in the human endometrium 2013
- Endometrial regeneration and endometrial stem/progenitor cells 2012
- A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice 2011
- Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma 2011
- Stem Cells in Endometriosis 2011
- Adult stem cells in the endometrium 2010
- Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model 2010
- The Endometrium: A Novel Source of Adult Stem/Progenitor Cells 2009
- Adult Stem Cells in the Human Endometrium 2009
- Adult Stem Cells in the Human Endometrium 2009
- Current understanding of endometrial stem cells 2009
- Hormone and growth factor signaling in endometrial renewal: role of stem/progenitor cells 2008
- Uterine stem cells: what is the evidence? 2006
- Higher frequency of chromosomal aberrations in ovarian endometriosis compared to extragonadal endometriosis: A possible link to endometrioid adenocarcinoma 2006
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:03:44.483075+00:00
- unpaywall
- last seen: 2026-10-17T06:24:38.187582+00:00
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