Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma

Kao AP, An‐Pei Kao, An-Pei Kao, Wang KH, Kai-Hung Wang, Kai‐Hung Wang, Cheng-Yu Long, Cheng‐Yu Long, Long CY, Chee-Yin Chai, Chee‐Yin Chai, Cheng‐Fang Tsai, Tsai CF, Cheng-Fang Tsai, Tsung-Hua Hsieh, Tsung‐Hua Hsieh, Hsieh TH, Chia‐Yi Hsu, Chia-Yi Hsu, Chang CC, Chia-Cheng Chang, Chia‐Cheng Chang, Lee JN, Jau-Nan Lee, Eing-Mei Tsai, Tsai EM, Eing‐Mei Tsai
Fertility and sterility · 2011 · vol. 96(3) , pp. 678–684.e1 · doi:10.1016/j.fertnstert.2011.06.041 · PMID:21762900 · W2029933078
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Interleukin-1β was found to increase cyclooxygenase-2 expression and enhance the invasive potential of human mesenchymal stem cells originating from ovarian endometriomas.

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Abstract

OBJECTIVE: To elucidate the role of interleukin-1β (IL-1β) on cyclooxygenase-2 (COX-2) expression and invasion of endometrioma-derived ectopic endometrial mesenchymal stem cells (EN-MSCs) and to develop an organoid method to study the invasive ability of endometrial cells. DESIGN: Gene expression and cell functions. SETTING: Kaohsiung Medical University, Kaohsiung, Taiwan. PATIENT(S): Human eutopic and endometrioma-derived ectopic EN-MSCs were isolated from different endometrium biopsy samples after surgery for treatment of endometriosis. INTERVENTION(S): Chemical treatment of cell culture. MAIN OUTCOME MEASURE(S): Comparative analysis of genomewide messenger RNA (mRNA) expression, cell migration, and invasion abilities in cell culture and organoid culture. RESULT(S): Gene expression profiles revealed that the expression of IL-1β and COX-2 were statistically significantly higher in ectopic EN-MSCs compared with eutopic EN-MSCs. These enhanced expressions coincided with a greater ability for cell migration and invasion in ectopic EN-MSCs and were found to be distinctly regulated by IL-1β which up-regulates COX-2 expression. Furthermore, IL-1β treatment of ectopic EN-MSCs in organoids was found to induce tentacle-like structures that mimicked cell invasion. CONCLUSION(S): These results indicate that COX-2 and IL-1β regulate the invasion ability of ectopic EN-MSCs. The information may be useful for developing a new therapeutic strategy for endometriosis. The ex vivo invasion model will be useful for characterization of EN-MSCs.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometrium Interleukin-1beta Mesenchymal Stem Cells Biopsy Biopsy Cell Movement Cell Movement Cell Movement Cells, Cultured Cells, Cultured Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Endometriosis Endometrium

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