Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis

Beata Smolarz, Hanna Romanowicz
Archives of gynecology and obstetrics · 2021 · vol. 304(2) , pp. 439–445 · doi:10.1007/s00404-021-06051-5 · PMID:33825969 · W3148119521
article OA: closed CC0 ⤵ 2 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study evaluated the association between specific single nucleotide polymorphisms (SNPs) in the ESR2 and CYP19A1 genes and endometriosis incidence in Polish women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This case-control study evaluated whether single nucleotide polymorphisms rs17179740 in ESR2 and rs2899470 in CYP19A1 are associated with endometriosis incidence, analyzing blood samples from 200 women with endometriosis and 200 age-matched endometriosis-free controls using high-resolution melting (HRM) for genotyping. The TT genotype for rs2899470 was significantly more common in endometriosis patients than controls (OR 2.19, p = 0.04), and for rs17179740 the GG homozygotes (OR 2.48, p = 0.04) as well as AG-AA genotypes (OR 2.36, p = 0.04) were significantly more prevalent among cases. The paper’s main limitation is that genotype association is reported without additional caveats in the abstract beyond the statistical comparisons and the fact that data sharing is restricted because results are part of a clinical database. This paper is centrally about endometriosis — it tests ESR2 (rs17179740) and CYP19A1 (rs2899470) SNP associations with endometriosis incidence.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Aromatase Endometriosis Estrogen Receptor beta Infertility Adult Aged Aromatase Case-Control Studies Endometriosis Endometriosis Estrogen Receptor beta Female Genetic Predisposition to Disease Genotype Humans Infertility Middle Aged Polymorphism, Single Nucleotide

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (2)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:43.494969+00:00
License: CC0 · commercial use OK