Androgen receptor cytosine, adenine, and guanine trinucleotide repeat polymorphism in Korean patients with endometriosis: A case-control study

Jae Jun Shin, Shin JJ, Choi YM, Young Min Choi, Choi HY, Hwa Young Choi, Soo Jin Chae, Hwang K, Kyuri Hwang, Jin Ju Kim, Jinju Kim, Kim JJ, Lee GH, Gyoung Hoon Lee, Kim JM, Jong Mi Kim
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 218 , pp. 1–4 · doi:10.1016/j.ejogrb.2017.09.005 · PMID:28915409 · W2751216286
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case-control study investigated the association between androgen receptor trinucleotide repeat polymorphisms (CAG, AAA, and GGN) and endometriosis in Korean patients.

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Abstract

Study objectiveTo investigate the association between the androgen receptor (AR) cytosine, adenine, and guanine (CAG) repeat polymorphisms and endometriosis.Study designA prospective case-control, genetic association study was performed on women with surgically proven endometriosis (n=421) and controls free of endometriosis (n=349). AR CAG repeat lengths were determined from peripheral blood samples. The difference in the frequency of each alleles were compared in patients with endometriosis and controls using Chi-square test.Main resultsNo significant difference in biallelic length mean between patients and controls was observed. Alleles containing 24 CAG repeats were significantly more frequent in stage I-II (mild) endometriosis than in the control samples (19.8% and 13.3%, respectively; OR 1.60, 95% CI 1.04-2.47). Additionally, a higher frequency of both alleles with 24 or more CAG repeats was observed in individuals with mild endometriosis, in comparison with the controls (25.6% and 15.2%, respectively; OR 1.92, 95% CI 1.09-3.38).ConclusionsAR gene CAG repeat polymorphisms are associated with the increased risk of mild endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adenine Cytosine Endometriosis Guanine Polymorphism, Genetic Receptors, Androgen Trinucleotide Repeats Alleles Case-Control Studies Chi-Square Distribution Endometriosis Endometriosis Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Polymerase Chain Reaction Prospective Studies Receptors, Androgen

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