Androgen receptor and 5α‐reductase are expressed in pelvic endometriosis

Márcia Mendonça Carneiro, M M Carneiro, DM Morsch, D M Morsch, A F Camargos, F M Reis, Fernando M. Reis, P M Spritzer, Poli Mara Spritzer
BJOG: An International Journal of Obstetrics & Gynaecology · 2007 · vol. 115(1) , pp. 113–117 · doi:10.1111/j.1471-0528.2007.01521.x · PMID:17983420 · W1999386715
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Androgen receptor, 5alpha-reductase 1, and 5alpha-reductase 2 were detected in pelvic endometriosis and eutopic endometrium, indicating active androgens may form locally to affect endometriotic cells.

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Abstract

The aim of this study was to evaluate whether androgen receptor (AR) and the enzymes that convert testosterone into the more potent androgen dihydrotestosterone, 5alpha-reductases (5alpha-R1 and 5alpha-R2) are expressed in pelvic endometriosis. The study involved 21 infertile women who underwent laparoscopy and were divided into two groups: control (n= 13) and endometriosis (n= 8) according to the histological and laparoscopic findings. Endometrial and endometriotic implant biopsies were performed. By reverse transcription polymerase chain reaction and immunohistochemistry, AR, 5alpha-R1 and 5alpha-R2 messenger RNA and protein were detected in biopsies of pelvic endometriosis, as well as in the eutopic endometrium of both groups. These findings suggest that active androgens may be formed within the endometriotic tissue and that both local and systemic androgens have the potential to act on endometriotic cells.

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Condition tags

endometriosis

MeSH descriptors

Cholestenone 5 alpha-Reductase Endometriosis Receptors, Androgen Adolescent Adult Case-Control Studies Cholestenone 5 alpha-Reductase Dihydrotestosterone Dihydrotestosterone DNA, Complementary DNA, Complementary Endometriosis Female Humans Immunohistochemistry Prognosis Receptors, Androgen Reverse Transcriptase Polymerase Chain Reaction

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Cited by (25)

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