Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis

M M Carneiro, Márcia Mendonça Carneiro, D M Morsch, DM Morsch, Morsch DM, A F Camargos, Camargos AF, F. M. Reis, Fernando M. Reis, P M Spritzer, Poli Mara Spritzer
BJOG: An International Journal of Obstetrics & Gynaecology · 2007 · vol. 115(1) , pp. 113–117 · doi:10.1111/j.1471-0528.2007.01521.x · PMID:17983420 · W1999386715
Other OA: closed CC0 ⤵ 25 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

Androgen receptor, 5alpha-reductase 1, and 5alpha-reductase 2 were detected in pelvic endometriosis and eutopic endometrium, indicating active androgens may form locally to affect endometriotic cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study was to evaluate whether androgen receptor (AR) and the enzymes that convert testosterone into the more potent androgen dihydrotestosterone, 5alpha-reductases (5alpha-R1 and 5alpha-R2) are expressed in pelvic endometriosis. The study involved 21 infertile women who underwent laparoscopy and were divided into two groups: control (n= 13) and endometriosis (n= 8) according to the histological and laparoscopic findings. Endometrial and endometriotic implant biopsies were performed. By reverse transcription polymerase chain reaction and immunohistochemistry, AR, 5alpha-R1 and 5alpha-R2 messenger RNA and protein were detected in biopsies of pelvic endometriosis, as well as in the eutopic endometrium of both groups. These findings suggest that active androgens may be formed within the endometriotic tissue and that both local and systemic androgens have the potential to act on endometriotic cells.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cholestenone 5 alpha-Reductase Endometriosis Receptors, Androgen Adolescent Adolescent Adult Adult Case-Control Studies Case-Control Studies Cholestenone 5 alpha-Reductase Cholestenone 5 alpha-Reductase Dihydrotestosterone Dihydrotestosterone Dihydrotestosterone DNA, Complementary DNA, Complementary DNA, Complementary Endometriosis Endometriosis Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (9)

Cited by (24)

Source provenance

europepmc
last seen: 2026-10-20T06:13:28.455750+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:04:47.165929+00:00
unpaywall
last seen: 2026-10-20T06:27:24.728081+00:00
License: CC0 · commercial use OK