Lack of Association Between Endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) Polymorphisms in a Japanese Population

Masashi Deguchi, Deguchi M, Yoshida S, Shigeki Yoshida, Kennedy S, Stephen Kennedy, Ohara N, Noriyuki Ohara, Motoyama S, Satoru Motoyama, Takeshi Maruo, Maruo T
Journal of the Society for Gynecologic Investigation · 2005 · vol. 12(3) , pp. 208–213 · doi:10.1016/j.jsgi.2005.01.008 · PMID:15784508 · W1848053799
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This study investigated the association between endometriosis and polymorphisms in the N-acetyl transferase 1 (NAT1) and 2 (NAT2) genes in a Japanese population and found no significant link.

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Abstract

ObjectiveWe investigated the association between endometriosis and polymorphisms in the N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) genes in a Japanese population, having previously demonstrated a positive association with NAT2 polymorphisms in a UK population.MethodsGenotyping for NAT1 alleles *3, *4, *10, and *11, and NAT2 alleles *4, *5A, *5B, *5C, *6A, and *7B was performed using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) and allele-specific PCR (AS-PCR) analysis in 145 ethnically Japanese, endometriosis patients and 182 controls. The NAT1 and NAT2 allele and genotype frequencies were compared in cases and controls using the Fisher exact test.ResultsNo significant differences between cases and controls were observed in the frequencies of the NAT1 and NAT2 alleles (P = .13; P = .91) and genotypes (P = .24; P = .79), and the NAT2 acetylation phenotypes (P = .46). Dividing the cases into a subgroup, consisting of women with severe disease only (n = 80), had no effect on the results.ConclusionThe distribution of NAT1 and NAT2 allele and genotype frequencies were not significantly different between Japanese cases and controls. Our findings suggest that polymorphisms in NAT1 and NAT2 are unlikely to be associated with an increased risk of endometriosis in the Japanese population.

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Condition tags

endometriosis

MeSH descriptors

Arylamine N-Acetyltransferase Endometriosis Polymorphism, Genetic Arylamine N-Acetyltransferase Asian People Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Humans Isoenzymes Japan Pregnancy

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