Risk of Gynecologic Cancer According to the Type of Endometriosis

Liisu Saavalainen, Heini Lassus, Anna But, But A, Tiitinen A, Aila Tiitinen, Härkki P, Päivi Härkki, Mika Gissler, ­Eero Pukkala, Eero Pukkala, Pukkala E, Oskari Heikinheimo
Obstetrics and gynecology · 2018 · vol. 131(6) , pp. 1095–1102 · doi:10.1097/aog.0000000000002624 · PMID:29742675 · W2802218891
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Surgically verified endometriosis is linked to an elevated risk of ovarian cancer, particularly endometrioid and clear cell subtypes, and this risk is highest among women with ovarian endometriosis.

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Abstract

OBJECTIVE: To assess the risks of gynecologic cancer according to the type of endometriosis in women with surgically verified endometriosis. METHODS: This is a population-based study of women with surgically verified endometriosis retrieved from the Finnish Hospital Discharge Register 1987-2012 (N=49,933); the subtypes of ovarian (n=23,210), peritoneal (n=20,187), and deep infiltrating (n=2,372) endometriosis were analyzed separately. Gynecologic cancers were obtained from the Finnish Cancer Registry. The outcome measure was the standardized incidence ratio (95% CI) calculated as the ratio between the observed to the expected number of cancers and defined for each gynecologic cancer and further stratified according to the histology, follow-up time since surgery, and age at follow-up. The follow-up was 838,685 person-years, and the Finnish female population served as the reference. RESULTS: Endometriosis was associated with increased risk of ovarian cancer (standardized incidence ratio 1.76 [95% CI 1.47-2.08]), especially with endometrioid (3.12 [2.15-4.38]) and clear cell (5.17 [3.20-7.89]) histologic type and to a lesser extent with serous type (1.37 [1.02-1.80]). The risk of ovarian cancer was highest among women with ovarian endometriosis and especially for endometrioid (4.72 [2.75-7.56]) and clear cell (10.1 [5.50-16.9]) ovarian cancer, occurring 5-10 years after the index surgery. The overall risk of ovarian cancer was not increased among women with peritoneal and deep infiltrating endometriosis. However, peritoneal endometriosis was associated with a twofold increase in risk of endometrioid histology. The risk of endometrial cancer was not altered in the entire cohort. The standardized incidence ratio for precancerous cervical lesions was 0.81 (0.71-0.92) and for invasive squamous cell carcinoma of the cervical cancer 0.46 (0.20-0.91). CONCLUSION: The excess risk of ovarian cancer among women with ovarian endometriosis translates into two excess cases per 1,000 patients followed for 10 years. Acknowledging these risks is important when planning long-term management of women with endometriosis.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Genital Neoplasms, Female Ovarian Neoplasms Adult Cohort Studies Endometriosis Endometriosis Female Finland Finland Genital Neoplasms, Female Genital Neoplasms, Female Humans Incidence Middle Aged Ovarian Neoplasms Ovarian Neoplasms Registries Risk Factors

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