Endometriose und assoziiertes Malignomrisiko

Sara Isabel Knochenhauer, Sebastian Daniel Schäfer, Ludwig Kiesel
In: Die Gynäkologie · 2023 · vol. 56(3) , pp. 213–218 · doi:10.1007/s00129-022-05051-z · W4318070816
article OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

This review synthesizes literature and guidelines regarding endometriosis and its association with various cancer risks, emphasizing ovarian cancer.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This article is a narrative review that addresses the relationship between endometriosis and associated malignancy risk, drawing on prior literature including guidelines and systematic reviews/meta-analyses of ovarian, gynecologic, and extra-gynecologic cancers. It summarizes evidence that women with endometriosis can have increased risks of certain cancers and discusses proposed pathophysiologic mechanisms and relevant genetic/molecular findings reported in the cited studies, while also noting that risk estimates vary by cancer type and study design. A key limitation is that, as a review, it synthesizes heterogeneous studies rather than providing new primary data or a single pooled estimate. Relevance to endometriosis: the paper’s full title and purpose are explicitly about “endometriose und assoziiertes Malignomrisiko,” integrating evidence on cancer risk in endometriosis, with some studies also considering adenomyosis as a related comparison condition.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 4,435 characters · extracted from oa-doi-fallback · click to expand
Literatur Diagnosis and therapy of endometriosis. Guideline of the DGGG, SGG and OEGGG (S2k-Level, AWMF Registry No. 045/015, August 2020). http://www.awmf.org/leitlinien/detail/ll/015-045.html. Zugegriffen: 09.01.2023 Anglesio MS, Papadopoulos N, Ayhan A et al (2017) Cancer-associated mutations in endometriosis without cancer. N Engl J Med 376(19):1835–1848 Hudelist G, Fritzer N, Thomas A et al (2012) Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod 27(12):3412–3416 Members of the Endometriosis Guideline Core Group, Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, King K, Kvaskoff M, Nap A, Petersen K, Saridogan E, Tomassetti C, van Hanegem N, Vulliemoz N, Vermeulen N, ESHRE Endometriosis Guideline Group (2022) ESHRE guideline: endometriosis. Hum Reprod Open 2022(2):hoac9. https://doi.org/10.1093/hropen/hoac009 Wilbur MA, le-Ming S, Segars JH et al (2017) Cancer implications for patients with endometriosis. Semin Reprod Med 35(1):110–116 Kvaskoff M, Mahamat-Saleh Y, Farland LV et al (2021) Endometriosis and cancer: a systematic review and meta-analysis. Hum Reprod Update 27(2):393–420 Gandini S, Lazzeroni M, Peccatori FA et al (2019) The risk of extra-ovarian malignancies among women with endometriosis: a systematic literature review and meta-analysis. Crit Rev Oncol Hematol 134:72–81 Melin A, Sparén P, Persson I et al (2006) Endometriosis and the risk of cancer with special emphasis on ovarian cancer. Hum Reprod 21(5):1237–1242 Saavalainen L, Lassus H, But A et al (2018) A nationwide cohort study on the risk of non-gynecological cancer in women with surgically verified endometriosis. Int J Cancer 143(11):2725–2731 Kvaskoff M, Mu FKLT et al (2015) Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update 21(4):500–516 Kim HS, Kim TH, Chung HH et al (2014) Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis. Br J Cancer 110(7):1878–1890 Saavalainen L, Lassus H, But A et al (2018) Risk of gynecologic cancer according to the type of endometriosis. Obstet Gynecol 131(6):1095–1102 Thomsen LH, Schnack TH, Buchardi K et al (2017) Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review. Acta Obstet Gynecol Scand 96(6):761–778 Farland LV, Tamimi RM, Eliassen AH et al (2017) Laparoskopically confirmed endometriosis and breast cancer in the nurses’health study II. Obstet Gynecol 128(5):1025–1031 Kok VC, Horng-Jyh TC-FS et al (2015) The risk for ovarian, endometrial, breast, colorectal, and other cancers in women with newly diagnosed endometriosis or adenomyosis: a population-based study. Int J Gynecol Cancer 25(6):968–976 Brøchner Mogensen J, Kjær SK, Mellemkjær L et al (2016) Endometriosis and risk for ovarian, endometrial and breast cancers: a nationwide cohort study. Gynecol Oncol 143(1):87–92 Kajiyama H, Suzuki S, Yoshihara M et al (2019) Endometriosis and cancer. Free Radic Biol Med 133:186–192 Guo S‑W (2020) Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology. Hum Reprod Update 26(3):423–449 Atsma F, Bartelink M‑LEL, Grobbee DE et al (2006) Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis. Menopause 13(2):265–279 Kvaskoff M, Horne AW, Missmer SA (2017) Informing women with endometriosis about ovarian cancer risk. Lancet 390(10111):2433–2434 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt S.I. Knochenhauer, S.D. Schäfer und L. Kiesel geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information Redaktion Tanja Fehm, Düsseldorf Ludwig Kiesel, Münster Rainer Kimmig, Essen Sara Isabel Knochenhauer und Sebastian Daniel Schäfer haben zu gleichen Teilen zum Manuskript beigetragen. QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Knochenhauer, S.I., Schäfer, S.D. & Kiesel, L. Endometriose und assoziiertes Malignomrisiko. Gynäkologie 56, 213–218 (2023). https://doi.org/10.1007/s00129-022-05051-z Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00129-022-05051-z

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK