CYFRA 21-1 Protein - a Potential Marker of Endometriosis

Alenka Višnić, Gordana Čanadi Jurešić, Dubravko Barišić, Nataša Smajla, Tina Sušanj Šepić, Neda Smiljan Severinski
In: Medicina Fluminensis · 2023 · vol. 59(3) , pp. 251–255 · doi:10.21860/medflum2023_306342 · W4386370194
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Cytokeratin 19-9 (CYFRA 21-1) protein is elevated in the urine of endometriosis patients, indicating its potential as an early diagnostic marker for this chronic inflammatory disease.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This narrative review discusses endometriosis as a chronic inflammatory disorder and proposes that invasion and proliferation processes could drive increased synthesis of certain proteins that are subsequently excreted in urine. It focuses on CYFRA 21-1, a protein derived from cytokeratin 19-9, stating that it is enhanced in urinary secretion in patients with endometriosis and may function as a potential marker, particularly in early stages where imaging cannot reliably suggest or target the diagnosis. The paper does not provide new primary data and, as a review, acknowledges etiopathogenesis remains insufficiently clarified with multiple theories. This paper is centrally about endometriosis—specifically evaluating CYFRA 21-1 in urine as a potential early-stage marker.

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Abstract

Endometrioza je kronična upalna bolest karakterizirana pojavom i rastom endometrija izvan maternice. Etiopatogeneza nije razjašnjena, a postoji više teorija nastanka endometrioze. Patološki procesi prisutni u endometriozi jesu adhezija, invazija, proliferacija, angiogeneza i promijenjena imunost. Moguće je da procesi invazije i proliferacije uzrokuju povećanu sintezu određenih proteina koji se zatim izlučuju urinom. Protein citokeratin 19-9 (CYFRA 21-1) pojačano se izlučuje u urinu pacijentica s endometriozom te je potencijalni marker u ranim stadijima ove bolesti kada nije moguće slikovnim metodama postaviti sumnju na bolest ili ciljanu dijagnozu.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

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last seen: 2026-06-10T17:14:06.276822+00:00
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