CYFRA 21-1 Protein - a Potential Marker of Endometriosis

Alenka Višnić, Gordana Čanadi Jurešić, Dubravko Barišić, Nataša Smajla, Tina Sušanj Šepić, Neda Smiljan Severinski
In: Medicina Fluminensis · 2023 · vol. 59(3) , pp. 251–255 · doi:10.21860/medflum2023_306342 · W4386370194
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Cytokeratin 19-9 (CYFRA 21-1) protein is elevated in the urine of endometriosis patients, indicating its potential as an early diagnostic marker for this chronic inflammatory disease.

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This narrative review discusses endometriosis as a chronic inflammatory disorder and proposes that invasion and proliferation processes could drive increased synthesis of certain proteins that are subsequently excreted in urine. It focuses on CYFRA 21-1, a protein derived from cytokeratin 19-9, stating that it is enhanced in urinary secretion in patients with endometriosis and may function as a potential marker, particularly in early stages where imaging cannot reliably suggest or target the diagnosis. The paper does not provide new primary data and, as a review, acknowledges etiopathogenesis remains insufficiently clarified with multiple theories. This paper is centrally about endometriosis—specifically evaluating CYFRA 21-1 in urine as a potential early-stage marker.

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Abstract

Endometrioza je kronična upalna bolest karakterizirana pojavom i rastom endometrija izvan maternice. Etiopatogeneza nije razjašnjena, a postoji više teorija nastanka endometrioze. Patološki procesi prisutni u endometriozi jesu adhezija, invazija, proliferacija, angiogeneza i promijenjena imunost. Moguće je da procesi invazije i proliferacije uzrokuju povećanu sintezu određenih proteina koji se zatim izlučuju urinom. Protein citokeratin 19-9 (CYFRA 21-1) pojačano se izlučuje u urinu pacijentica s endometriozom te je potencijalni marker u ranim stadijima ove bolesti kada nije moguće slikovnim metodama postaviti sumnju na bolest ili ciljanu dijagnozu.
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Medicina Fluminensis, Vol. 59 No. 3, 2023. Pregledni rad https://doi.org/10.21860/medflum2023_306342 Protein CYFRA 21-1 - potencijalni marker endometrioze Alenka Višnić ; Klinički bolnički centar Rijeka, Klinika za ginekologiju i porodništvo, Zavod za humanu reprodukciju, Rijeka, Hrvatska Gordana Čanadi Jurešić ; Sveučilište u Rijeci, Medicinski fakultet, Katedra za medicinsku kemiju, biokemiju i kliničku kemiju, Rijeka, Hrvatska Dubravko Barišić ; Specijalna bolnica Radiochirurgia Zagreb, Zagreb, Hrvatska Nataša Smajla ; Klinički bolnički centar Rijeka, Klinika za ginekologiju i porodništvo, Zavod za humanu reprodukciju, Rijeka, Hrvatska Tina Sušanj Šepić ; Klinički bolnički centar Rijeka, Klinika za ginekologiju i porodništvo, Zavod za humanu reprodukciju, Rijeka, Hrvatska Neda Smiljan Severinski ; Klinički bolnički centar Rijeka, Klinika za ginekologiju i porodništvo, Zavod za humanu reprodukciju, Rijeka, Hrvatska Sažetak Endometrioza je kronična upalna bolest karakterizirana pojavom i rastom endometrija izvan maternice. Etiopatogeneza nije razjašnjena, a postoji više teorija nastanka endometrioze. Patološki procesi prisutni u endometriozi jesu adhezija, invazija, proliferacija, angiogeneza i promijenjena imunost. Moguće je da procesi invazije i proliferacije uzrokuju povećanu sintezu određenih proteina koji se zatim izlučuju urinom. Protein citokeratin 19-9 (CYFRA 21-1) pojačano se izlučuje u urinu pacijentica s endometriozom te je potencijalni marker u ranim stadijima ove bolesti kada nije moguće slikovnim metodama postaviti sumnju na bolest ili ciljanu dijagnozu. Ključne riječi Hrčak ID: 306342 URI Datum izdavanja: 1.9.2023. Posjeta: 1.812 *

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endometriosis

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