Peer Review #2 of "Genetic links between endometriosis and cancers in women (v0.1)"

2019 · doi:10.7287/peerj.8135v0.1/reviews/2 · W4230918211
peer-review OA: gold CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study integrated literature, gene expression, and cancer genomics data to identify 39 key endometriosis-related genes involved in tumor formation and progression, including C3AR1, a novel linker gene, and PGR and ESR1, shared with four cancers.

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Abstract

Endometriosis is a chronic disease occurring during the reproductive stage of women.Although there is only limited association between endometriosis and gynecological cancers with regard to clinical features, the molecular basis of the relationship between these diseases is unexplored.We conducted a systematic study by integrating literature-based evidence, gene expression and large-scale cancer genomics data in order to reveal any genetic relationships between endometriosis and cancers in women.We curated 984 endometriosisrelated genes from 3270 PubMed articles and then conducted a meta-analysis of the two public gene expression profiles related to endometriosis which identified Differential Expression of Genes (DEGs).Following an overlapping analysis, we identified 39 key endometriosis-related genes common in both literature and DEG analysis.Finally, the functional analysis confirmed that all the 39 genes were associated with the vital processes of tumour formation and cancer progression and that two genes (PGR and ESR1) were common to four cancers of women.From network analysis, we identified a novel linker gene, C3AR1, which had not been implicated previously in endometriosis.The shared genetic mechanisms of endometriosis and cancers in women identified in this study provided possible new avenues of multiple disease management and treatments through early diagnosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (96)

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