HPV infection and endometriosis: a systematic review and meta-analysis

Geilson Gomes de Oliveira, José Eleutério, Renata Mírian Nunes Eleutério
In: Jornal Brasileiro de Doenças Sexualmente Transmissíveis · 2019 · vol. 31(4) , pp. 138–142 · doi:10.5327/dst-2177-8264-201931406 · W3096391804
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This meta-analysis of studies on HPV infection and endometriosis found a twofold increased risk of HPV exposure in women with endometriosis compared to controls.

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Abstract

Introduction: Recent research has focused on the role of persistent ascending bacterial infections and sexually transmitted infections (STI) as a factor associated to endometriosis. Indeed, some studies investigated the possible role of HPV in endometriosis, but this topic remains inconclusive. Objective:The present study aims to meta-analyze research that assessed the presence of HPV infection in patients with endometriosis. Methods: MEDLINE, Embase, Scopus, LILACS, Cochrane Library, and OpenGrey were searched until February 10th, 2020. Search terms included “endometriosis” and “HPV” without language restrictions. The combined relative risks and 95% confidence interval (95%CI) were calculated, and heterogeneity was assessed with I-square (I2 ). Results: Meta-analysis with low heterogeneity found a relative risk of twice as much in women exposed to HPV in relation to the unexposed control. Conclusion: Results indicate that HPV could be a risk factor for developing endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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