The effects of isoliquiritigenin on endometriosis in vivo and in vitro study

Hsu YW, Yi-Wen Hsu, Y-H. Chen, Hsin-Yuan Chen, Yi-Fen Chiang, Chiang YF, Chang LC, Li-Chun Chang, Po‐Han Lin, Po-Han Lin, Lin PH, Shih-Min Hsia, Shih‐Min Hsia
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2020 · vol. 77 , pp. 153214 · doi:10.1016/j.phymed.2020.153214 · PMID:32736296 · W3029341037
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Isoliquiritigenin reduced endometriotic lesion size and suppressed proliferation and invasion of endometrial cells in vitro.

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Abstract

BackgroundEndometriosis is a common gynaecological disease characterized by growth of uterine endometrial tissue, outside the uterine cavity, on the ovaries, oviduct and pelvic peritoneum. Isoliquiritigenin (ISL) is a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis) and shallot (Allium cepa). ISL has previously shown antioxidant, anti-inflammatory, anti-proliferation and anti-tumor activities.PurposeThis study aimed to investigate the effects of ISL on endometriosis in vivo and in vitro.MethodsEnd1/E6E7 endometriosis cells were treated with ISL and β-estradiol. The MTT assay was used to detect cell viability. Cell migration was evaluated by the wound-healing assay. The expression of epithelial-to-mesenchymal transition (EMT)-related proteins were detected by western blot. Female Balb/c mice, surgically induced to have endometriosis by transplanting uterine tissue into the abdominal cavity, were treated with ISL or vehicle for 4 weeks. Lesion growth was subsequently analyzed by high-resolution ultrasound imaging. Serum and lesion inflammatory cytokines were measured by ELISA. EMT-related proteins and apoptosis-related proteins of endometriotic lesions were detected by western blot.ResultsIt was observed that ISL treatment inhibited the viability and migration of End1/E6E7. ISL treatment increased the expression of E-cadherin, and decreased the expression of N-cadherin, Slug and Snail. In the animal model, ISL treatment reduced the volume and weight of endometriotic lesions, decreased serum and lesion inflammatory cytokines, inhibited EMT, and induced apoptosis of the lesions.ConclusionISL inhibited the viability, migration and EMT-related proteins of End1/E6E7 cells, reduced the volume and weight of endometriotic lesions, inhibited inflammatory cytokines and EMT, and induced apoptosis of the lesions to improve endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Chalcones Endometriosis Endometriosis Animals Antigens, CD Antigens, CD Cadherins Cadherins Cell Line Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cell Survival Cell Survival Chalcones Disease Models, Animal Endometriosis Endometriosis Epithelial-Mesenchymal Transition

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