Nutrients

Background/Objectives: Dietary fiber and polyphenols are recognized modulators of intestinal and immune homeostasis; however, evidence regarding their combined impact under physiological conditions remains limited. This study aimed to evalu…

BACKGROUND/OBJECTIVES: Breast Milk Feeding (BMF) benefits mother and infant. However, women with select risk factors report shorter breastfeeding durations. Our previous prospective cohort observational study of a lactation-consultant-led t…

Background/Objectives: Infertility is a multifactorial condition influenced by both medical factors and lifestyle-related determinants, including diet quality and nutritional supplementation. However, it is unclear which dietary patterns ar…

Background/Objectives: A pilot study was conducted to evaluate the effectiveness of treatment with autoprobiotic bacteria from indigenous, non-pathogenic Enterococcus faecium and Enterococcus hirae strains in patients with metabolic syndrom…

BACKGROUND/OBJECTIVES: Polyendocrine Metabolic Ovarian Syndrome (PMOS) is a common endocrine disorder affecting women of reproductive age. Current international evidence-based guidelines promote lifestyle management, including diet and nutr…

Fisetin is a naturally occurring flavonoid, a type of polyphenol found in fruits and vegetables such as strawberries, apples, persimmons, and onions. It has gained increasing attention for its antioxidant properties (enhancement of SOD1 and…

BACKGROUND: Spermidine is involved in a wide range of cellular processes, including mammalian oocyte development. Wheat germ is a natural source of polyamines and contains high concentrations of spermidine. However, no studies have evaluate…

Background/Objective: Coffee is the most highly consumed beverage worldwide, and coffee drinkers exhibit decreased mortality and protection from aging-related diseases. This study investigates the role of orphan nuclear receptor 4A1 (NR4A1)…

BACKGROUND/OBJECTIVES: Botanical supplements are increasingly investigated for their potential to address women's health concerns. Compounds that modulate progesterone receptor (PR) signaling may help manage gynecologic disorders such as en…

Background/Objectives: Endometriosis is a chronic estrogen-dependent disease with a complex and incompletely understood etiology. Environmental exposure to toxic elements, including cadmium, lead, mercury, and arsenic, may contribute to its…

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder. It is associated with hormonal dysregulation, pelvic pain, and a reduced quality of life. Dietary factors may influence disease development and symptom severi…

BACKGROUND: Infertility is a major public health concern worldwide. While excess body weight is a well-established risk factor for impaired fertility, increasing evidence indicates that elevated body fat content may also occur in women with…

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder associated with pain and immune dysregulation. Omega-3 (n-3) fatty acids and fish-derived bioactive lipids may modulate inflammation and metabolism. This study…

According to the World Health Organization (WHO), all countries face major challenges in adapting health and social systems to the rapid aging of the population, as the proportion of people over 60 is expected to nearly double from 12% to 2…

BACKGROUND/OBJECTIVES: Vitamin D deficiency and insufficiency represent a widespread problem in the majority of Central Asian countries, attributable to the geographical location of the region, urbanization, and dietary patterns of the popu…

BACKGROUND/OBJECTIVES: Obesity is a complex systemic condition driven by interactions between biological mechanisms and environmental factors. This retrospective, uncontrolled, completer study aimed to evaluate changes in body composition a…

Objective: Nutrition is a key determinant of women's health across all life stages. Clinical practice remains heterogeneous because of lack of evidence and non-homogeneous guidelines. Despite growing research on micronutrient supplementatio…

Background/Objectives: Gastrointestinal (GI) symptoms, including abdominal pain, bloating, altered stool pattern, dyschezia, and nausea, are frequent in women with endometriosis and may persist despite conventional gynecological treatment. …

Endometriosis is a chronic estrogen-dependent systemic inflammatory disorder characterized by ectopic implantation of endometrial-like tissue, primarily on the ovaries, pelvic peritoneum, and bowel. According to the World Health Organizatio…

Background/Objectives: Oxidative stress plays an important role in the pathophysiology of endometriosis, contributing to inflammation, immune dysregulation, and lesion progression. This has led to growing interest in antioxidant-based strat…

Ovarian function is critically dependent on tightly coordinated cellular energy metabolism, which governs follicular development, oocyte competence, and reproductive longevity. Increasing evidence indicates that metabolic dysregulation, inc…

Cardiovascular and cerebrovascular diseases (CVDs) are closely associated with disturbances in vascular homeostasis, including endothelial dysfunction, abnormal vascular remodeling, inflammation, oxidative stress, thrombosis, barrier disrup…

Background/Objectives: To examine relationships between maternal-serum 25(OH)D levels at preconception and 8 weeks' gestation and the risk of vaginal bleeding and subchorionic hemorrhage during pregnancy. Methods: A secondary analysis of th…

Background/Objectives: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by reproductive and metabolic dysfunction. Vitamin D deficiency is common in women with PCOS and is linked to adverse metabolic and repr…