Evidence-Based Nutraceuticals in Human Health and Longevity Medicine.

Antonelli M, Donelli D
Nutrients · 2026 · doi:10.3390/nu18060935 · PMID:41901110 · PMC13029078
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This review discusses evidence-based nutraceuticals for human health and longevity medicine, addressing global challenges posed by the rapid aging of the population.

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This editorial serves as a guest introduction to a special issue of Nutrients focused on the evidence-based role of nutraceuticals in promoting human health and longevity. It acknowledges the contributions of various authors who published studies ranging from vegetable biofortification and dietary patterns to the effects of hawthorn fruit and quail egg supplements on specific conditions. The text highlights a narrative review within this collection that investigates epigallocatechin gallate as a potential therapeutic agent for endometriosis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

According to the World Health Organization (WHO), all countries face major challenges in adapting health and social systems to the rapid aging of the population, as the proportion of people over 60 is expected to nearly double from 12% to 22% between 2015 and 2050, and since the year 2020 older adults have already outnumbered children under 5 years globally [...].
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Ack

As Guest Editors of the Special Issue, “Nutraceuticals’ Role in Promoting Human Health and Well-Being: An Evidence-Based Perspective”, we would like to express our appreciation to all authors whose valuable work was published in this issue and contributed to its success.

Data

All data are available by contacting the corresponding author.

List

Baldassano, S.; Di Rosa, L.; Cortis, C.; Cannizzaro, A.; Fiore, A.S.; Sabatino, L.; Vasto, S.; Proia, P. Biofortification of Vegetables with Iodine and Molybdenum for Healthy Nutrition: A Controlled Trial. Nutrients   2025 , 18 , 2. https://doi.org/10.3390/nu18010002 . Campos, M.J.; Garbacz, A.; Czlapka-Klapinska, N.; Czlapka-Matyasik, M.; Pena, A. Exploring the Lifestyle and Dietary Patterns of Food Supplement and Non-Food Supplement Users: A Cross-Sectional Study in the Portuguese Population. Nutrients   2025 , 17 , 2802. https://doi.org/10.3390/nu17172802 . Kim, M.; Baik, I. Effects of Hawthorn Fruit Supplementation on Facial Skin Phenotypes and Leukocyte Telomere Length Stratified by Polymorphisms. Nutrients   2025 , 17 , 1983. https://doi.org/10.3390/nu17121983 . Ribeiro, P.R.; Ferreira, C.; Antunes, C.; Dias, G.; Lima, M.J.; Guiné, R.; Teixeira-Lemos, E. Nutritional Approaches in Neurodegenerative Disorders: A Mini Scoping Review with Emphasis on SPG11-Related Conditions. Nutrients   2025 , 17 , 3344. https://doi.org/10.3390/nu17213344 . Markowska, A.; Kojs, Z.; Antoszczak, M.; Markowska, J.; Huczyński, A. Epigallocatechin Gallate as a Potential Therapeutic Agent in Endometriosis: A Narrative Review. Nutrients   2025 , 17 , 2068. https://doi.org/10.3390/nu17132068 . Antonelli, M.; Mazzoleni, E.; Donelli, D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients   2025 , 17 , 712. https://doi.org/10.3390/nu17040712 .

Author

Conceptualization, M.A. and D.D.; methodology, M.A. and D.D.; validation, M.A. and D.D.; data curation, M.A. and D.D.; writing—original draft preparation, M.A. and D.D.; writing—review and editing, M.A. and D.D.; supervision, M.A. and D.D.; project administration, M.A. and D.D. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Fn Group

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Informed

Not applicable.

Conflicts

The authors declare no conflicts of interest.

Institutional

Not applicable.

Associated Data

All data are available by contacting the corresponding author.

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