Tissue Inhibitor of Metalloproteinase-1 Concentrations are Attenuated in Peritoneal Fluid and Sera of Women with Endometriosis and Restored in Sera by Gonadotropin-Releasing Hormone Agonist Therapy
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This study found that women with endometriosis have lower levels of tissue inhibitor of metalloproteinase-1 in peritoneal fluid and serum, which are restored in serum after gonadotropin-releasing hormone agonist therapy.
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Abstract
ObjectiveTo establish tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in peritoneal fluid (PF) and sera of women with endometriosis and compare them to disease-free controls.DesignProspective randomized study.SettingAcademic medical center.Patient(s)Women with laparoscopically documented endometriosis and disease-free women of reproductive age.Intervention(s)Peritoneal fluid and sera were collected, and some women received gonadotropin-releasing hormone agonist (GnRH-a) therapy for endometriosis.Main outcome measure(s)Peritoneal fluid and sera TIMP-1 concentrations were measured with a specific RIA.Result(s)The TIMP-1 concentrations were significantly lower in PF and sera of women with endometriosis compared with disease-free women. The GnRH-a therapy restored serum TIMP-1 concentrations.Conclusion(s)Aberrant expression and localization of TIMP-1 may derange the proteolytic milieu of the peritoneal cavity and contribute to the etiology and underlying physiologic sequelae associated with endometriosis. Measurement of TIMP-1 in serum may aid in diagnosing endometriosis and assist with monitoring treatment efficacy in women with this disease.
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- Endometriosis Research: From Bench to Bedside 2022
- Endometriosis diagnosis and medical treatment: Present and future 2021
- Miscarriage Rates Due to Endometriosis: A Retrospective Cohort Study 2020
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights 2019
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) 2018
- GnRH agonist administration prior to embryo transfer in freeze-all cycles of patients with endometriosis or aberrant endometrial integrin expression 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
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- Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies 2015
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- Effect of Long Protocol on the Outcome of In Vitro Fertilization-embryo Transfer in Patients with Endometriosis Compared with Prolonged Protocol 2014
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- Reduced Fecundity in Female Rats with Surgically Induced Endometriosis and in Their Daughters: A Potential Role for Tissue Inhibitors of Metalloproteinase 11 2008
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- Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis 2008
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- Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression 2003
- Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis 2003
- An evidence-based evaluation of endometriosis-associated infertility 2003
- Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? 2003
- Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? 2003
- Management of endometriosis-associated infertility 2003
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