Miscarriage Rates Due to Endometriosis: A Retrospective Cohort Study

Pınar Çalış, Gizem Işık, Dilara Duygulu Bulan, Nuray Bozkurt, Deniz Karçaaltıncaba
In: Gynecology Obstetrics & Reproductive Medicine · 2020 · vol. 27(2) , pp. 128–131 · doi:10.21613/gorm.2020.1058 · W3016804339
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⚙ AI-generated summary by claude@2026-07, 2026-07-13 ⓘ

This retrospective cohort study found no significant difference in miscarriage rates between patients with and without endometriosis, but identified higher miscarriage rates in IVF pregnancies with endometriomas compared to those without.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-13 · read from full text ⓘ

This retrospective cohort study (2015–2018) from a single obstetrics/gynecology department compared miscarriage rates between pregnant patients with confirmed endometriosis and those without, using pathology reports and ultrasound to define groups. In 62 endometriosis and 65 non-endometriosis patients, overall miscarriage rates were not significantly different (32% vs 20%), and the paper notes that no endometriosis/non-endometriosis effect was observed in the combined analysis. A significant difference in miscarriage rates was found between in vitro fertilization and non–in vitro fertilization pregnancies, and within the in vitro fertilization subgroup miscarriage was higher in patients with endometrioma than in those without endometrioma (p=0.008). This paper is centrally about endometriosis — specifically, miscarriage rates in pregnancies of patients with endometriosis and the endometrioma subgroup.

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Abstract

OBJECTIVE: To find the differences of miscarriage rates between pregnant patients with and without endometriosis. STUDY DESIGN: The retrospective cohort study was conducted in the Department of Obstetrics and Gynecology, School of Medicine, Gazi University between January-2015 and December-2018. Patients were divided into two groups; endometriosis and non-endometriosis according to their pathology report and ultrasound examination. In both groups, miscarriage rates and in vitro fertilization pregnancy ratios were analyzed. Miscarriage rates in in vitro fertilization pregnancies and in endometriosis group who had and didn't have surgery also analyzed.RESULTS: Sixty-two patients in the study group and 65 patients in the control group were included. There was no significant difference in miscarriage rates between endometriosis and non-endometriosis group (20/62 (32%) and 13/65 (20%), respectively, p=0.124). There was a statistically significant difference in miscarriage rates between in vitro fertilization and non-in vitro fertilization group (p=0.004). Apart from that, in in vitro fertilization group, the miscarriage rate was higher in the endometrioma subgroup than non-endometrioma (p=0.008).CONCLUSION: There was an only significant difference in miscarriage rate in the in vitro fertilization group between endometrioma and non-endometrioma patients. In the future, there should be more studies to define the actual pathophysiology for miscarriage with endometriosis.
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Objective

To find the differences of miscarriage rates between pregnant patients with and without endometriosis. STUDY DESIGN: The retrospective cohort study was conducted in the Department of Obstetrics and Gynecology, School of Medicine, Gazi University between January-2015 and December-2018. Patients were divided into two groups; endometriosis and non-endometriosis according to their pathology report and ultrasound examination. In both groups, miscarriage rates and in vitro fertilization pregnancy ratios were analyzed. Miscarriage rates in in vitro fertilization pregnancies and in endometriosis group who had and didn't have surgery also analyzed.

Results

Sixty-two patients in the study group and 65 patients in the control group were included. There was no significant difference in miscarriage rates between endometriosis and non-endometriosis group (20/62 (32%) and 13/65 (20%), respectively, p=0.124). There was a statistically significant difference in miscarriage rates between in vitro fertilization and non-in vitro fertilization group (p=0.004). Apart from that, in in vitro fertilization group, the miscarriage rate was higher in the endometrioma subgroup than non-endometrioma (p=0.008).

Conclusion

There was an only significant difference in miscarriage rate in the in vitro fertilization group between endometrioma and non-endometrioma patients. In the future, there should be more studies to define the actual pathophysiology for miscarriage with endometriosis. Downloads Downloads Published How to Cite Issue Section License Copyright (c) 2020 Pinar Calis, Gizem Isik, Dilara Duygulu, Nuray Bozkurt, Deniz Karcaaltincaba This work is licensed under a Creative Commons Attribution 4.0 International License. All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.

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endometriosisendometrioma

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