Gonadotropin-releasing hormone agonist treatment reduced serum interleukin-6 concentrations in patients with ovarian endometriomas

Tomio Iwabe, Iwabe T, Harada T, Tasuku Harada, Sakamoto Y, Yasuko Sakamoto, Yumiko Iba, Iba Y, Sayako Horie, Horie S, Mitsunari M, Masahiro Mitsunari, Terakawa N, Naoki Terakawa
Fertility and sterility · 2003 · vol. 80(2) , pp. 300–304 · doi:10.1016/s0015-0282(03)00609-5 · PMID:12909491 · W2027572168
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Gonadotropin-releasing hormone agonist treatment led to a decrease in serum interleukin-6 concentrations in patients diagnosed with ovarian endometriomas.

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Abstract

ObjectiveTo determine whether serum interleukin (IL)-6 can be measured in patients with ovarian endometriomas and whether these measurements are useful in managing this disease.DesignA controlled clinical study and an in vitro study.SettingDepartment of Obstetrics and Gynecology, Tottori University, Japan.Twenty-two patients with ovarian endometriomas.Intervention(s)Laparoscopic cystectomy for ovarian endometriomas was performed. Gonadotropin-releasing hormone (GnRH) agonist was administered for 3 months in nine patients before laparoscopic surgery. Endometriotic stromal cells obtained from patients with endometriomas with or without GnRH agonist treatment were cultured.Main outcome measures(s)IL-6 concentrations in serum or supernatant of the cell culture were measured using ELISA.ResultsThe serum concentration of IL-6 in patients with endometriomas was higher at the time of diagnosis than in those without endometriomas. Laparoscopic surgery significantly reduced serum levels of IL-6. Serum IL-6 concentrations also decreased after treatment with GnRH agonist. IL-6 production was attenuated in the endometriotic stromal cells obtained from patients with GnRH agonist treatment compared with patients without such treatment.Conclusion(s)GnRH agonist treatment may decrease IL-6 production in endometriotic cells. Measurement of serum IL-6 concentrations may be of value in managing patients with endometriomas.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Gonadotropin-Releasing Hormone Interleukin-6 Ovarian Diseases Ovarian Diseases Adult Cells, Cultured Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Gonadotropin-Releasing Hormone Gynecologic Surgical Procedures Humans Interleukin-6 Interleukin-6 Laparoscopy Osmolar Concentration

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