Serum Soluble CD163 and Interleukin-6 Levels in Women with Ovarian Endometriomas

Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Shin Yong Moon
Gynecologic and obstetric investigation · 2008 · vol. 66(1) , pp. 47–52 · doi:10.1159/000119091 · PMID:18311079 · W2032938986
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Serum levels of soluble CD163 and interleukin-6 were evaluated in women with ovarian endometriomas and other adnexal benign cystic tumors, finding no significant differences among groups.

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Abstract

BACKGROUND: CD163 is a hemoglobin scavenger receptor exclusively expressed in the monocyte-macrophage system and its soluble form (sCD163) has not yet been studied as a serum marker in women with endometriosis. The purpose of this study was to evaluate whether serum levels of sCD163 and interleukin-6 (IL-6) could be possible markers for ovarian endometriomas discriminating adnexal benign cystic tumors. METHODS: The concentrations of sCD163 and IL-6 were determined using commercial ELISA kits in frozen sera collected from 95 women prior to surgery for adnexal benign cystic tumors: 44 with ovarian endometriomas, 24 with mature cystic teratomas, 10 with mucinous cystadenomas, 8 with serous cystadenomas and 9 with parovarian cysts. Serum levels of CA-125 were also recorded preoperatively. The volume of cysts was evaluated in women with ovarian endometriomas. RESULTS: The serum levels of sCD163 and IL-6 were not significantly different among the women with various adnexal benign cystic tumors. In patients with endometriomas (n = 44), the levels were similar to those with nonendometriotic benign cystic tumors (n = 51): 3,431.7 +/- 343.9 vs. 3,231.0 +/- 391.7 ng/ml for sCD163 and 5.3 +/- 0.9 vs. 12.9 +/- 4.0 pg/ml for IL-6 (mean +/- SEM). No correlation was noted between serum levels of two markers with volume of endometriomas. CONCLUSION: Our findings suggest that serum levels of sCD163 as well as IL-6 are not useful markers for ovarian endometriomas.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Antigens, CD Antigens, Differentiation, Myelomonocytic Endometriosis Interleukin-16 Ovarian Diseases Receptors, Cell Surface Adult Antigens, CD Antigens, Differentiation, Myelomonocytic Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen CD163 Antigen Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-16 Middle Aged

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