IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas

Paula Carolina Arvelos Crispim, Jammal MP, Millena Prata Jammal, Antão PKA, Priscylla Kelliny Aparecida Antão, Douglas Côbo Micheli, Micheli DC, Tavares-Murta BM, Beatriz Martins Tavares‐Murta, Beatriz Martins Tavares-Murta, Eddie Fernando Candido Murta, Eddie Fernando Cândido Murta, Rosekeila Simões Nomelini
American journal of reproductive immunology (New York, N.Y. : 1989) · 2020 · vol. 84(6) , pp. e13309 · doi:10.1111/aji.13309 · PMID:32698242 · W3043939711
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This study found that elevated serum concentrations of IL-6, IL-8, and IL-10 can differentiate ovarian malignancies from endometriomas.

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Abstract

PROBLEM: Studies have shown a relationship between endometriosis and ovarian cancer. Our aims were to evaluate and compare the dosages of cytokines IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α in serum, intracystic fluid, and peritoneal fluid of patients with ovarian endometrioma, malignant and benign ovarian neoplasms, and non-neoplastic ovarian tumors; to verify if there is a correlation between the values of these cytokines between ovarian endometrioma and ovarian malignancy; and to determine the best cut-off point for serum cytokines that can be used to differentiate patients with ovarian malignancy and endometrioma. METHOD OF STUDY: The concentrations of cytokines were quantified by enzyme-linked immunosorbent assay (ELISA), analyzed by Kruskal-Wallis test with the Dunn post-test. Receiver operating feature (ROC) curve was used to obtain the area under the curve (AUC) and to determine the best cut-off values that could be used in the diagnosis of ovarian malignancy. Correlations of cytokine concentrations were performed by the Spearman test. RESULTS: IL-6, IL-8, and IL-10 concentrations were higher in patients with malignant neoplasia. When evaluating the area under the curve (AUC) of serum cytokine levels comparing patients with malignant neoplasia and endometriomas, there was statistical significance for IL-6, IL-8, and IL-10. CONCLUSION: Our results showed utility in serum concentrations of IL-6, IL-10, and IL-8 as parameters that differentiate endometriomas from ovarian malignancies.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Interleukin-10 Interleukin-6 Interleukin-8 Neoplasms Ovarian Neoplasms Adolescent Adult Aged Biomarkers, Tumor Child Diagnosis, Differential Endometriosis Female Humans Interleukin-10 Interleukin-6 Interleukin-8 Middle Aged Neoplasms

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