Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy

Kathy L. Sharpe-Timms, Sharpe-Timms KL, K L Sharpe-Timms, Keisler LW, L W Keisler, Lydia W. Keisler, E W McIntush, McIntush EW, Eric W. McIntush, Keisler DH, D. H. Keisler
Fertility and sterility · 1998 · vol. 69(6) , pp. 1128–1134 · doi:10.1016/s0015-0282(98)00075-2 · PMID:9627304 · W2084545339
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This study found that women with endometriosis have lower levels of tissue inhibitor of metalloproteinase-1 in peritoneal fluid and serum, which are restored in serum after gonadotropin-releasing hormone agonist therapy.

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Abstract

OBJECTIVE: To establish tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in peritoneal fluid (PF) and sera of women with endometriosis and compare them to disease-free controls. DESIGN: Prospective randomized study. SETTING: Academic medical center. PATIENT(S): Women with laparoscopically documented endometriosis and disease-free women of reproductive age. INTERVENTION(S): Peritoneal fluid and sera were collected, and some women received gonadotropin-releasing hormone agonist (GnRH-a) therapy for endometriosis. MAIN OUTCOME MEASURE(S): Peritoneal fluid and sera TIMP-1 concentrations were measured with a specific RIA. RESULT(S): The TIMP-1 concentrations were significantly lower in PF and sera of women with endometriosis compared with disease-free women. The GnRH-a therapy restored serum TIMP-1 concentrations. CONCLUSION(S): Aberrant expression and localization of TIMP-1 may derange the proteolytic milieu of the peritoneal cavity and contribute to the etiology and underlying physiologic sequelae associated with endometriosis. Measurement of TIMP-1 in serum may aid in diagnosing endometriosis and assist with monitoring treatment efficacy in women with this disease.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Gonadotropin-Releasing Hormone Tissue Inhibitor of Metalloproteinase-1 Administration, Inhalation Administration, Inhalation Adult Adult Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans Osmolar Concentration

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