Oocyte Donation

Ernesto Bosch, Sandra Almeida Reis, Javier Domingo, José Remohı́
In: Infertility and Assisted Reproduction · 2008 · pp. 443–447 · doi:10.1017/cbo9780511547287.051 · W1584920803
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Oocyte donation yields the highest pregnancy rates in assisted reproduction, offering insights into reproductive physiology while acknowledging factors like age, smoking, BMI, and endometriosis that influence implantation, potentially benefiting from GnRH analogs.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This chapter on oocyte donation (OD) describes OD as an assisted reproduction technique associated with the highest pregnancy rates compared with other ART methods, and frames OD as a model for learning aspects of reproductive physiology relevant to broader ART applications. It discusses controversies and factors affecting IVF and implantation outcomes, including recipient age, smoking, BMI, and endometriosis, and outlines mechanisms by which endometriosis may impair uterine receptivity via endocrine/paracrine effects and immune changes. The chapter notes that GnRH analogs may positively affect endometrial cell physiology in patients with endometriosis, while also acknowledging evidence on endometriosis impacts from studies included in the chapter. This paper is centrally about endometriosis in the specific sense that it summarizes how endometriosis may alter uterine receptivity and how GnRH analogs could affect endometrial physiology within the oocyte donation and broader ART context.

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Abstract

Pregnancy rates obtained with oocyte donation (OD) are the highest when compared to any other assisted reproduction technique (ART). OD is not only the solution for many infertile couples but also a reference model for obtaining useful knowledge of the physiology of reproduction and consequently to be applied in other ART. One of the controversies regarding ovarian stimulation for in vitro fertilization (IVF) regards the impact that successive cycles could have on oocyte recovery in terms of quality and quantity of the obtained oocytes. Age of the recipient, smoking, body mass index (BMI), and endometriosis are the various factors influencing embryo implantation. Endometriosis could affect uterine receptivity through alteration of the local environment by means of endocrine and paracrine mechanisms or due to changes in immune response. Gonadotropin-releasing hormone (GnRH) analogs could have a positive effect on the physiology of endometrial cells of patients with endometriosis.

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endometriosis

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