Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Hye Won Chung, Chung HW, Ji Young Lee, Lee JY, Hye-Sung Moon, Moon HS, Hye Sung Moon, Sung Eun Hur, Hur SE, Mi Hye Park, Park MH, Yan Wen, Wen Y, Mary Lake Polan, Polan ML
Fertility and sterility · 2002 · vol. 78(4) , pp. 787–795 · doi:10.1016/s0015-0282(02)03322-8 · PMID:12372458 · W2085585495
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This study investigated the expression of matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 in both ectopic and eutopic endometrial tissues.

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Abstract

OBJECTIVE: To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without endometriosis throughout the menstrual cycle. DESIGN: Molecular studies in human tissue. SETTING: Reproductive immunology laboratory of a university medical center. PATIENT(S): Fifty-three premenopausal woman (23 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery. Endometrium and ectopic endometriosis tissue were obtained at the time of surgery. MAIN OUTCOME MEASURE(S): Messenger RNA and protein expression from eutopic and ectopic endometrium was analyzed by using quantitative competitive polymerase chain reaction, zymography, and Western blot assay. RESULT(S): Uterine endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women. CONCLUSION(S): Eutopic endometrium from patients with endometriosis may be more invasive and prone to peritoneal implantation because of greater expression of MMP-2 and MT1-MMP and lower expression of TIMP-2 messenger RNA, compared with endometrium from women without endometriosis. Thus, increased proteolytic activity may help to explain the invasive factors that result in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Gene Expression Matrix Metalloproteinase 2 Metalloendopeptidases Tissue Inhibitor of Metalloproteinase-2 Adult Adult Blotting, Western Blotting, Western Electrophoresis, Polyacrylamide Gel Electrophoresis, Polyacrylamide Gel Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female

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