Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis

Artymuk NV, Natalia V Artymuk, Н. В. Артымук, V.O. Chervov, Danilova LN, Larissa N. Danilova, Polenok EG, Elena G Polenok, Е. Г. Поленок, О. А. Зотова, Olga Zotova, Zotova O
Hormone molecular biology and clinical investigation · 2021 · vol. 42(3) , pp. 285–289 · doi:10.1515/hmbci-2020-0056 · PMID:33684279 · W3135625342
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This study found that women with endometriosis have significantly higher levels of IgA and IgG antibodies to estradiol, progesterone, and benzo[a]pyrene, identifying specific threshold values for these antibodies as risk factors.

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Abstract

OBJECTIVES: The objective of the study was to determine the level of antibodies (AB) of Ig classes A and G to estradiol (E2), progesterone (P) and benzo [a] pyrene (Bp) in patients with endometriosis of various severity and estimate their threshold values as a risk factor for the development of endometriosis. METHODS: A retrospective case-control study was performed. The study involved 200 women. Group I: women with endometriosis (n=100), Group II: patients with tubal-peritoneal infertility (n=100). All patients underwent immunological studies of blood serum; and the levels of steroid hormones (P, E2), antibodies to them and Bp were determined. A ROC analysis was carried out to identify threshold values of antibodies levels. RESULTS: Women with endometriosis were found to have statistically significantly higher levels of antibodies IgA and IgG to E2, P and benzo [a] pyrene compared to women of Group II. The threshold levels of IgA-Bp, IgA-E2 and IgA-P are >5 CU (conventional unit), IgG-Bp, IgG-E2>9 CU and IgG-P>8 CU. The level of IgG-P in patients with severe forms of endometriosis is statistically significantly higher than in minor forms of the disease. In case of severe forms, there is a tendency to increasing other classes of antibodies. CONCLUSIONS: Patients with endometriosis usually have a higher level of IgA and IgG to Bp, E2, P. Their threshold values, which are risk factors for the development of the disease, are estimated.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Autoantigens Benzo(a)pyrene Disease Susceptibility Endometriosis Estrogens Progesterone Adolescent Adult Autoantibodies Autoantibodies Autoantigens Case-Control Studies Disease Susceptibility Endometriosis Endometriosis Endometriosis Estrogens Female Humans

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References (16)

SciLite annotations

chemicals 8
estrogen progesterone tryptophol [xylosyl-(1->6)-glucoside] estradiol progesterone tryptophol [xylosyl-(1->6)-glucoside] steroid hormone tryptophol [xylosyl-(1->6)-glucoside]

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