Novel targets for the treatment of endometriosis

Nothnick WB, Warren B. Nothnick
Expert opinion on therapeutic targets · 2004 · vol. 8(5) , pp. 459–471 · doi:10.1517/14728222.8.5.459 · PMID:15469395 · W2089627518
review OA: closed CC0 ⤵ 5 in-corpus citations
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This review discusses current endometriosis treatments and their limitations, highlighting novel therapeutic targets such as TNF inhibitors for future treatment development.

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Abstract

Endometriosis is an enigmatic, debilitating disease that affects up to 15% of all women of reproductive age. It is characterised by pelvic pain and infertility. Current treatment regimens control the disease by inducing a hypoestrogenic state. Although the absence of circulating oestrogen levels leads to a regression of the disease, this hypoestrogenism also induces many unpleasant side effects. As such, these and other shortcomings of current drug therapies emphasise their limitations and the necessity for the development of novel endometriosis treatments. In this review, current therapies for medical management of endometriosis are discussed, as are their shortcomings. Potential target areas that may be attractive alternatives to current therapies are also reviewed. Emphasis is placed upon the emerging research using TNF inhibitors, their potential benefits over current treatment regimens and the development of future potential therapeutic targets.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Adolescent Adult Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Ascitic Fluid Ascitic Fluid Cell Adhesion Molecules Cell Adhesion Molecules Cell Adhesion Molecules Cytokines Cytokines Cytokines

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (96)

Cited by (5)

SciLite annotations

chemicals 1
estrogen

Source provenance

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License: CC0 · commercial use OK