Depressive symptoms associated with gonadotropin-releasing hormone agonists

Warnock JK, Julia K. Warnock, J K Warnock, J. Clark Bundren, J C Bundren, Bundren JC, D W Morris, Morris DW, David W. Morris
Depression and anxiety · 1998 · vol. 7(4) , pp. 171–177 · doi:10.1002/(sici)1520-6394(1998)7:4<171::aid-da5>3.0.co;2-d · PMID:9706454 · W2110044941
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GnRH agonist therapy for endometriosis is associated with increased depressive symptoms, possibly due to estrogen decline, and sertraline may effectively manage these mood changes.

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Abstract

The gonadotropin-releasing hormone (GnRH) agonists are a relatively new class of drugs that are potentially effective in treating disorders that are aggravated either by estrogen or testosterone. GnRH agonists are effective in the treatment of endometriosis, as well as other disorders, such as advanced prostrate cancer, precocious puberty and uterine leiomyomata. While the GnRH agonists reduce the extent of the endometrial lesions and the occurrence of pelvic pain associated with endometriosis, these agents are associated with physical and psychiatric side effects. The adverse effects of these agents are consistent with the physiological effects of ovarian suppression, such as vasomotor instability, vaginal dryness, and headaches. Preliminary results of a prospective, double-blind placebo-controlled study and an open label trial indicates that depressive mood symptoms increase in women treated with GnRH agonist therapy for endometriosis. Additional evidence suggest that sertraline effectively manages depressive mood symptoms associated with GnRH agonist therapy. The reason for the decline in mood on GnRH agonists is postulated to be associated with the decline in estrogen levels. Effective treatment strategies for depressive mood symptoms in women on GnRH agonists therapy may offer insight into the mechanisms of action of estrogen on mood.

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Condition tags

endometriosis

MeSH descriptors

Depressive Disorder Endometriosis Gonadotropin-Releasing Hormone Adult Antidepressive Agents, Second-Generation Antidepressive Agents, Second-Generation Depressive Disorder Depressive Disorder Depressive Disorder Double-Blind Method Endometriosis Female Gonadotropin-Releasing Hormone Goserelin Goserelin Goserelin Humans Leuprolide Leuprolide Leuprolide

Citation neighborhood

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