Substance p sp and neurokinin‐1 receptor nk‐1r as biomarkers of pain and stressSP and NK-1R are neuropeptide related biomarkers involved in nociceptive pathways. Dysmenorrhea is frequently associated with psychological distress and biochemi…
This research has suggested a link between major depressive disorder (MDD) and infertility, with interleukin-18 (IL-18) being proposed as a potential mediator due to its connections to both conditions. A Mendelian randomization (MR) approac…
BackgroundPeripartum depression is a common complication with potential long-term adverse effects on the woman and her family. Approximately 30%-50% of newly delivered women experience prolonged depressive symptoms at 6-12 months postpartum…
BACKGROUND: Hormonal fluctuations may trigger the onset of bipolar disorder. We designed a longitudinal follow-up study to evaluate the association between hysterectomies and bipolar disorder risk. METHODS: We conducted a large retrospecti…
BackgroundAlthough traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomi…
The gonadotropin-releasing hormone (GnRH) agonists are a relatively new class of drugs that are potentially effective in treating disorders that are aggravated either by estrogen or testosterone. GnRH agonists are effective in the treatment…