Studies on the effect of the new non-steroidal aromatase inhibitor fadrozole hydrochloride in an endometriosis model in rats.
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Abstract
The therapeutic effect of the new nonsteroidal aromatase inhibitor fadrozole hydrochloride (4-(5,6,7,8-tetrahydro-imidazo[1,5a]pyridin-5-yl)benzonitrile monohydrochloride, fadrozole, CAS 102676-31-3, CGS16949A) was assessed using a surgically induced endometriosis model in rats. In nontreated rats, the endometrial transplants on the abdominal wall developed large cysts with fluid. In the fadrozole treated group, the cystic volume of the transplants decreased in a dose-dependent manner. The weights of the hemi-uteri were markedly reduced by fadrozole treatment. Fadrozole produced a dose-dependent increase in percentage of vaginal diestrous days. In ovariectomized group, the growth of the transplants was also suppressed, and the weights of the hemi-uteri decreased markedly. Histologically, the signs of growth suppression and/or atrophic changes such as minimization of luminal size, cuboidal piknotic epithelium and/or contraction of stroma were observed in ovariectomized or fadrozole treated groups. The right uterine horns also showed marked atrophic changes as with the transplants. The present study strongly indicates that the new selective aromatase inhibitor fadrozole should be useful for the treatment of endometriosis.
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Cited by (15)
- Treatment of Endometriosis with Local Acetylsalicylic Acid Injection: Experimental Study in Rabbits 2011
- Brief update on endometriosis treatment 2011
- Are aromatase inhibitors effective in endometriosis treatment? 2011
- Emerging drugs for endometriosis 2008
- Investigational drugs for endometriosis 2006
- Aromataseinhibitoren zur Therapie der Endometriose? 2005
- Endometriosis: New Genetic Approaches and Therapy 2005
- Future Perspectives in the Medical Treatment of Endometriosis 2005
- New medical treatments for endometriosis 2004
- Emerging drugs for endometriosis 2004
- Future Directions in Endometriosis Research 2004
- Novel targets for the treatment of endometriosis 2004
- Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? 2003
- Medical Management of Endometriosis: Novel Targets and Approaches towards the Development of Future Treatment Regimes 2003
- Endometriosis: novel etiopathogenetic concepts and clinical perspectives 2002
SciLite annotations
chemicals 3
fadrozole hydrochloride
fadrozole hydrochloride
benzonitrile
organisms 3
rattus sp.
rattus sp.
rattus sp.
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