Lupron-induced mania

Michael Rachman, M Rachman, Rachman M, Garfield DA, D A Garfield, David Garfield, Rachman I, Ilya M. Rachman, I Rachman, Rochelle S. Cohen, R. Cohen, Cohen R
Biological psychiatry · 1999 · vol. 45(2) , pp. 243–244 · doi:10.1016/s0006-3223(98)00206-6 · PMID:9951575 · W2040286939
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-22 ⓘ

This case report describes a patient who developed manic symptoms during treatment with leuprolide acetate for prostate cancer.

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Abstract

BackgroundGonadotropins and sex hormones are intimately related to the stability of affective states. Patients with affective disorders may demonstrate abnormal levels of sex hormones and gonadotropins. It is therefore possible that affective disorder patients may experience mood dysregulation by synthetic sex hormones and gonadotropins like lupron.MethodsA case report of a young woman with a history of endometriosis and a past history of irritability and depression is described. Treatment of the endometriosis with lupron induced a manic episode.ResultsThe lupron-induced mania was successfully treated with a mood-stabilizing agent, lithium carbonate.ConclusionsPatients with a history of affective disorder may develop manic episodes when treated with Lupron. Mood-stabilizing agents are helpful in ameliorating this unwanted effect.

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Condition tags

endometriosis

MeSH descriptors

Bipolar Disorder Fertility Agents, Female Leuprolide Adult Antimanic Agents Antimanic Agents Bipolar Disorder Bipolar Disorder Endometriosis Endometriosis Female Fertility Agents, Female Humans Leuprolide Lithium Carbonate Lithium Carbonate

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Cited by (4)

References (6)

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Source provenance

europepmc
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License: CC0 · commercial use OK