Anti-inflammatory effects of selected dietary components on endometriosis - review

Agata Pawłowska, Piotr Zatyka, Adam Słomczyński, Dominika Opala, Michał Rabenda, Dobromiła Osuch, Piotr Janik
In: Quality in Sport · 2024 · vol. 21 , pp. 54047 · doi:10.12775/qs.2024.21.54047 · W4401810844
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review analyzes studies on polyphenols, vitamin D, and omega-3 fatty acids, finding they possess anti-inflammatory and cell-proliferative inhibitory properties beneficial for endometriosis treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper is a narrative review that analyzes PubMed studies on the anti-inflammatory effects of selected dietary components—polyphenols (including resveratrol and curcumin), vitamin D3, and omega-3/polyunsaturated fatty acids—in relation to endometriosis-associated inflammation, pain, and endometrial proliferation. It reports that these dietary components have been described across the literature as potentially reducing inflammatory marker levels and modulating mechanisms such as cytokine/prostaglandin-related inflammation, angiogenesis (for vitamin D3), and cell proliferation/invasiveness (for polyphenols and omega-3s). The review emphasizes a critical appraisal of efficacy and notes that, despite promising findings, further clinical trials are needed. This paper is centrally about endometriosis — it specifically reviews dietary components with reported anti-inflammatory effects as potential therapeutic options for endometriosis.

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Abstract

Background: Endometriosis is a chronic inflammatory disorder that is among the most common gynaecological problems in women of reproductive age. The disease involves the presence of endometrial tissue outside the uterus, which manifests as pelvic pain and infertility. The main theory for its development suggests that endometrial cells move into the abdominal cavity during menstruation and implant there. This process leads to an increase in inflammatory cells and increased concentrations of cytokines, chemokines and prostaglandins, resulting in chronic inflammation. Objective: The aim of this work is to analyse in detail the available studies on the anti-inflammatory effects of selected dietary components such as polyphenols, vitamin D and omega-3 fatty acids. The work aims to evaluate their potential as future therapeutic options for the treatment of endometriosis, with a critical approach to their efficacy and possible application in the treatment of this disease.Materials and methods: A review of the literature available in the PubMed database was conducted using the following phrases in English: endometriosis, pain, diet, polyphenols, resveratrol, curcumin, vitamin D3, OMEGA-3 acids, polyunsaturated acidsState of knowledge: Changing dietary patterns in patients with endometriosis may result in a reduction in levels of inflammatory markers, which are typically elevated in this disease. Polyphenols, such as resveratrol and curcumin, show anti-inflammatory effects and inhibit endometrial cell proliferation. Vitamin D3 shows anti-inflammatory effects and influences angiogenesis. Omega-3 fatty acids may reduce inflammation and endometrial proliferation.Conclusions: The literature review indicates that polyphenols, vitamin D3 and omega-3 fatty acids offer promising therapeutic properties for the treatment of endometriosis, with anti-inflammatory and proliferative, pain-relieving effects. Despite these promising results, further clinical trials are needed.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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