Periostin Enhances Migration, Invasion, and Adhesion of Human Endometrial Stromal Cells Through Integrin-Linked Kinase 1/Akt Signaling Pathway

Xiaoxuan Xu, Qiaomei Zheng, Zongzheng Zhang, Xiaolei Zhang, Ruihan Liu, Peishu Liu
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 22(9) , pp. 1098–1106 · doi:10.1177/1933719115572481 · PMID:25759370 · W2039869127
article OA: closed CC0 ⤵ 20 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Periostin enhances human endometrial stromal cell migration, invasion, and adhesion by activating the integrin-linked kinase 1/Akt signaling pathway.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study examined whether periostin (PN) affects human endometrial stromal cell (ESC) behaviors—migration, invasion, adhesion, and proliferation—and investigated the mechanism involving integrin-linked kinase 1 (ILK1) and phospho-Akt (p-Akt). ESCs were isolated from eutopic, ectopic, and normal endometrium, and PN, ILK1, and p-Akt levels were assessed before and after PN knockdown using PN small-interfering RNA; PN protein was reported as upregulated in both eutopic and ectopic ESCs compared with normal ESCs, and in ectopic ESCs migration, invasion, adhesion, ILK1, and p-Akt were enhanced and then reduced by PN siRNA. The paper does not report PN effects on proliferation with clear mechanistic outcomes, and statistical comparisons are uneven (e.g., PN mRNA differences noted lack significance), which may limit interpretation of broader functional impacts. This paper is centrally about endometriosis — it tests PN’s role in endometrial stromal cell invasiveness through the ILK1/Akt signaling pathway, directly building on PN overexpression in eutopic and ectopic endometriosis-associated stroma.

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Condition tags

endometriosis

MeSH descriptors

Cell Adhesion Cell Adhesion Molecules Cell Movement Endometriosis Endometrium Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Signal Transduction Stromal Cells Adult Cell Adhesion Molecules Cell Adhesion Molecules Cell Proliferation Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female

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