Looking Into Adhesion Formation and Its Relationship With Endometriosis

Maria Rosa Maduro
In: Reproductive Sciences · 2017 · vol. 24(8) , pp. 1101 · doi:10.1177/1933719117718096 · W3047697696
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

This review discusses endometriosis and its relationship with adhesion formation, citing various studies on animal models, ex vivo development, therapeutic targets, and molecular mechanisms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This article is a research-oriented discussion on how surgical adhesions form and how they relate to endometriosis, drawing on preclinical work that models adhesion development and tests interventions. It highlights studies in animal and ex vivo systems that examine mechanisms such as inflammation and specific signaling pathways, and contrasts these with related models of uterine or intrauterine adhesions. A major limitation is that the evidence assembled is primarily derived from model systems and literature synthesis rather than presenting new, direct human experimental data in this paper itself. This paper is centrally about endometriosis — specifically focusing on adhesion formation and the relationship between endometriosis and postsurgical or related surgical adhesions.

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Article PDF References Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268–279. Herington JL, Crispens MA, Carvalho-Macedo AC, et al. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil Steril. 2011;95(4):1295–1301.e1. Saed GM, Fletcher NM, Diamond MP. The creation of a model for ex vivo development of postoperative adhesions. Reprod Sci. 2016;23(5):610–612. Cai H, Li H, He Y. Interceed and estrogen reduce uterine adhesions and fibrosis and improve endometrial receptivity in a rabbit model of intrauterine adhesions. Reprod Sci. 2016;23(9):1208–1216. Xu X, Zheng Q, Zhang Z, Zhang X, Liu R, Liu P. Periostin enhances migration, invasion, and adhesion of human endometrial stromal cells through integrin-linked kinase 1/Akt signaling pathway. Reprod Sci. 2015;22(9):1098–1106. Liu X, Duan H, Zhang HH, Gan L, Xu Q. Integrated data set of microRNAs and mRNAs involved in severe intrauterine adhesion. Reprod Sci. 2016;23(10):1340–1347. Makker A, Goel MM, Nigam D, et al. Endometrial expression of homeobox genes and cell adhesion molecules in infertile women with intramural fibroids during window of implantation. Reprod Sci. 2017;24(3):435–444. Quattrone F, Sanchez AM, Pannese M, et al. The targeted delivery of interleukin 4 inhibits development of endometriotic lesions in a mouse model. Reprod Sci. 2015;22(9):1143–1152. Stocks MM, Crispens MA, Ding T, Mokshagundam S, Bruner-Tran KL, Osteen KG. Therapeutically targeting the inflammasome product in a chimeric model of endometriosis-related surgical adhesions. Reprod Sci. 2017;24(8):1121–1128. Rights and permissions About this article Cite this article Maduro, M.R. Looking Into Adhesion Formation and Its Relationship With Endometriosis. Reprod. Sci. 24, 1101 (2017). https://doi.org/10.1177/1933719117718096 Published: Issue date: DOI: https://doi.org/10.1177/1933719117718096

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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