Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis

Szczepańska M, Malgorzata Szczepańska, Małgorzata Szczepańska, Wirstlein P, Przemyslaw Wirstlein, Przemysław Wirstlein, Jana Skrzypczak, Skrzypczak J, Paweł P. Jagodzińśki, Paweł P Jagodziński
Acta obstetricia et gynecologica Scandinavica · 2013 · vol. 92(10) , pp. 1188–1193 · doi:10.1111/aogs.12210 · PMID:23809139 · W2069213593
article OA: bronze CC0 ⤵ 18 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

The CYP17 -34 G variant was associated with an increased risk of stage I-II endometriosis in women from a Polish population.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: Endometriosis is recognized as an estrogen-dependent disease. There are conflicting data demonstrating single nuclear polymorphisms (SNPs) of CYP17 and CYP19 steroidogenic genes as related to endometriosis risk. We assessed the CYP17 5'-untranslated region -34 A/G (rs743572) and CYP19 Ex10 + C1558T (rs10046) SNPs in stage I-II endometriosis. DESIGN: Case-control study. SETTING: Division of reproduction at a university department in Poland. POPULATION: A total of 115 women with diagnosed stage I-II endometriosis according to the revised American Society for Reproductive Medicine (rASRM) classification and 197 fertile women as controls. METHODS: The SNPs CYP17 -34 A/G and CYP19 Ex10 + C1558T were identified by high-resolution melting curve analysis. MAIN OUTCOME MEASURES: Genotype prevalence and odds ratio for recessive and dominant genetic model for CYP17 and CYP19 SNPs. RESULTS: We observed a significantly increased CYP17 GG and GA genotype frequency in women diagnosed with rASRM stage I-II endometriosis compared with fertile women (OR = 2.4; 95% CI 1.4-4.2, p = 0.002). We also found a significantly increased CYP17 G allele frequency in cases compared with controls (OR = 1.6; 95% CI 1.2-2.2, p = 0.004). There were no significant differences in the distribution of the CYP17 GG genotype and CYP19 Ex10 + C1558T polymorphism between women diagnosed with rASRM stage I-II endometriosis and controls. CONCLUSION: The CYP17 -34 G variant, previously associated with increased 17β-estradiol production, displayed a contribution to stage I-II endometriosis in women from a Polish population. Increased 17β-estradiol concentration in carriers of the CYP17 -34 G variant might contribute to endometriosis and associated pathological processes.

My notes (saved in your browser only)

Outcome instruments

rASRM

Condition tags

endometriosisinfertility

MeSH descriptors

Aromatase Endometriosis Infertility, Female Polymorphism, Single Nucleotide Steroid 17-alpha-Hydroxylase Adult Aromatase Case-Control Studies Endometriosis Endometriosis Female Genetic Markers Genotype Humans Infertility, Female Infertility, Female Poland Risk Factors Severity of Illness Index Steroid 17-alpha-Hydroxylase

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (18)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:59.468224+00:00
License: CC0 · commercial use OK