Aromatase Expression in Endometriosis and Its Significance

Hiroshi Ishikawa, Makio Shozu
In: Endometriosis · 2014 · pp. 155–178 · doi:10.1007/978-4-431-54421-0_11 · W253023194
book-chapter OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Aromatase is highly expressed in endometriosis, producing estrogen locally and contributing to disease progression, with potential therapeutic targeting by aromatase inhibitors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews how aromatase, the key estrogen-biosynthesis enzyme, is highly expressed in endometriotic tissue and can produce estrogen locally, potentially driving lesion growth and progression. It describes additional steroid enzyme changes (increased 17β-hydroxysteroid dehydrogenase type 1 and absent 17β-hydroxysteroid dehydrogenase type 2) that would raise tissue estrogen concentrations, and explains proposed regulatory mechanisms at the CYP19A1 transcriptional and epigenetic levels, highlighting the activity of promoter PII and CpG island hypomethylation. A stated caveat is that regulation of aromatase is complex and occurs across multiple layers, which limits straightforward causal interpretation, despite the mechanistic model presented. This paper is centrally about endometriosis — it focuses on aromatase expression and its significance for local estrogen production in endometriotic lesions and as a therapeutic target.

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endometriosis

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