The Use of Aromatase Inhibitors for Ovulation Induction and Superovulation

Mary Ellen Pavone, Bulun Se, Serdar E. Bulun
The Journal of clinical endocrinology and metabolism · 2013 · vol. 98(5) , pp. 1838–1844 · doi:10.1210/jc.2013-1328 · PMID:23585659 · PMC3644592 · W2063113300
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Aromatase inhibitors show promise as safe and effective alternatives to clomiphene citrate for inducing ovulation and superovulation in infertile patients.

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Abstract

CONTEXT: Anovulation is likely responsible for 20% of female infertility. Although clomiphene citrate remains the first-line therapy for ovulation induction in anovulatory patients who are not estrogen-deficient and to treat unexplained infertility, there remains a discrepancy between ovulation and conception rates with its use, attributed to its antiestrogenic effects on cervical mucus and the endometrium. Alternative agents, including aromatase inhibitors, have been used that have not been associated with these side effects. EVIDENCE ACQUISITION: A literature search was conducted to specifically explore the use of aromatase inhibitors for ovulation induction and superovulation. EVIDENCE SYNTHESIS: Recent studies have found that aromatase inhibitors may be safe and useful agents for ovulation induction in patients with polycystic ovarian syndrome as well a treatment option for superovulation in patients with either unexplained infertility or endometriosis. CONCLUSIONS: Aromatase inhibitors may be an effective alternative treatment to clomiphene citrate for both ovulation induction and superovulation.

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Condition tags

endometriosisinfertility

MeSH descriptors

Anovulation Aromatase Inhibitors Evidence-Based Medicine Ovulation Induction Ovulation Induction Superovulation Algorithms Anovulation Anovulation Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Decision Trees Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female

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