CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility

Lili Cong, Qiang Fu, Tianming Gao
Medicine · 2018 · vol. 97(28) , pp. e11415 · doi:10.1097/md.0000000000011415 · PMID:29995789 · W2868595767
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The CYP17A1 rs743572 TT genotype and T allele were associated with increased endometriosis susceptibility in this case-control study, but not with disease stage or characteristics.

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Abstract

This case-control study was aimed to evaluate the influence of cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene rs743572 polymorphism for the susceptibility to endometriosis.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype rs743572 polymorphism in 143 endometriosis patients and 148 healthy controls. Hardy-Weinberg equilibrium (HWE) test was utilized to detect the representativeness of the study subjects. Association strength was presented by odds ratios (ORs) with corresponding 95% confidence intervals (CIs).Genotype distribution of rs743572 polymorphism was conformed to HWE test both in case and control groups, revealing the good representativeness of our study subjects. Significantly positive association was discovered between rs743572 TT genotype and endometriosis susceptibility (P = .042, OR = 1.952, 95% CI = 1.020-3.736). Rs743572 T allele was more frequently discovered in cases than that in controls, revealing the enhanced susceptibility to endometriosis (P = .041, OR = 1.407, 95% CI = 1.014-1.951). Confounding factors (age and body mass index) were utilized to adjust the results, and then we found that the association strength had no significant changes (TT vs CC, P = .039, OR = 1.961, 95% CI = 1.023-3.742; T vs C, P = .038, OR = 1.413, 95% CI = 1.016-1.957). But we failed to find any obvious association of rs743572 genotypes with endometriosis stages and characteristics.T allele of rs743572 polymorphism might act as a risk factor for endometriosis, although it had no effects on the disease stages and basic features.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Polymorphism, Single Nucleotide Steroid 17-alpha-Hydroxylase Adult Case-Control Studies Endometriosis Endometriosis Female Genotype Humans Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Retrospective Studies Severity of Illness Index Steroid 17-alpha-Hydroxylase

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