Catechol-O-methyltransferase 158G/A polymorphism and endometriosis/adenomyosis susceptibility: A meta-analysis in the Chinese population

Yongyi Bi, Yong-Wei Li, Yongwei Li, Chun-Xia Wang, Chunxia Wang, Jian-She Chen, Jianshe Chen, Lu Chen, Lu Xu, Xiao-Qian Zhang, Yue Hu, Xiaoqian Zhang, Xiao-Bin Niu, Xiaobin Niu, Dong-Xu Pei, Xin-Wei Liu, Dongxu Pei, Xinwei Liu, Yong-Yi Bi
Journal of cancer research and therapeutics · 2018 · vol. 14(12) , pp. 980 · doi:10.4103/0973-1482.188439 · PMID:30539833 · W2883929419
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This meta-analysis of Chinese populations found the COMT 158G/A polymorphism is significantly associated with an increased risk of endometriosis and adenomyosis, particularly adenomyosis.

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Abstract

PURPOSE: An association between catechol-O-methyltransferase (COMT) 158G/A polymorphism and endometriosis/adenomyosis susceptibility has been reported in the previous studies, but the results were inconsistent. This study was conducted to explore this association in the Chinese population using meta-analysis. MATERIALS AND METHODS: PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine were searched for all relevant studies published up to December 2015. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations. RESULTS: A total of 7 case-control studies including 782 cases and 700 controls were included in this meta-analysis. Overall, COMT 158G/A polymorphism was found to be significantly associated with endometriosis and adenomyosis risk in the Chinese population (A vs. G, OR = 1.21, 95% CI: 1.02-1.42; AA vs. GG, OR = 1.47, 95% CI: 1.01-2.14; AA vs. GG + GA, OR = 1.42, 95% CI: 0.99-2.03; AA + GA vs. GG, OR = 1.20, 95% CI: 0.97-1.49). In subgroup analyses stratified by ethnicity, source of controls and disease groups, the significant risk was found in Chinese not mentioned the ethnicity, in population-based studies and adenomyosis. CONCLUSIONS: COMT 158G/A polymorphism may contribute to the risk of endometriosis and adenomyosis in Chinese, particularly for adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Asian People Catechol O-Methyltransferase Endometriosis Genetic Predisposition to Disease Adenomyosis Alleles Asian People Catechol O-Methyltransferase Endometriosis Female Humans Odds Ratio Polymorphism, Single Nucleotide Risk Factors

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