Analysis of the COMT Gene Met Polymorphism with Endometriosis Relationship

Objective Analysis of the COMT gene Met polymorphism with endometriosis relationship.Methods From 2011 June to 2012 June in our hospital during the period 100 endometriosis patients into test group(including 45 patients with adenomyosis),with proteinase K digestion-saturated phenol chloroform method on peripheral blood cell genomic DNA extraction,and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP method for more patients) were genotyped,another takes the same period 100 patients did not suffer from endometriosis(including 50 cases of patients with adenomyosis) patients as control group and test group,taking the same way of genotyping.Results Comparison of the two groups of G/G,G/A,A/A genotype frequency,wherein the test group were 38%,37%,25%,the control group were 40%,41%,19%,two groups of contrast difference is small,no statistical significance,P0.05;in contrast to the two group of Aallele frequencies,experiment group 42.3%,control group for 34.1%,a smaller difference between the two groups,no statistical significance,P0.05.Conclusions The COMT gene Met polymorphism with endometriosis without obvious correlation.