Study on the correlation between gene polymorphism of COMT and endometriosis

Objective To explore the correlation between gene polymorphism of Catechol-O-Methyltransferase(COMT) and endometriosis(EMs).Methods Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) was used to analyze the polymorphism of COMT gene in 120 patients with endometriosis(59 with adenomyosis) and 65 healthy controls.Results There was no significant difference of the frequence of A allele and the distribution of genotype between EMs group and control group.The relative risk suffered from endometriosis of G/A and A/A genotype was 0.516(0.185-1.441) and 0.450(0.165-1.232) times of the G/G genotype respectively.Conclusion There was no correlation between the Met gene polymorphism of COMT and endometriosis.