Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?

Vera Lúcia Rodrigues Lobo, José Maria Soares, Manuel de Jesus Simões, Ricardo dos Santos Simões, Ricardo Santos Simões, Geraldo Rodrigues de Lima, Edmund C Baracat
Clinics (Sao Paulo, Brazil) · 2008 · vol. 63(4) , pp. 525–530 · doi:10.1590/s1807-59322008000400019 · PMID:18719766 · W1991737099
article OA: gold CC0 ⤵ 6 in-corpus citations
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Gestrinone antagonized estrogen's effects on endometrial implants in a rat model, reducing macroscopic increases and morphometric development like gland proliferation and leukocyte infiltration.

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Abstract

OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen's effects on rat peritoneal endometrial implants.
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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Estrogen Antagonists Estrogens Gestrinone Progestins Animals Disease Models, Animal Drug Evaluation, Preclinical Endometriosis Endometriosis Estrogen Antagonists Estrogens Female Gestrinone Ovariectomy Progestins Rats Rats, Wistar

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