Individual and combined effects of triptoreline and gestrinone on experimental endometriosis in rats

F Quereda, Francisco Quereda, Júlia Cristina Vieira Barroso, Barroso J, J Barroso, Pedro Acién, P Acién, Acién P
European journal of obstetrics, gynecology, and reproductive biology · 1996 · vol. 67(1) , pp. 35–40 · doi:10.1016/0301-2115(96)02435-9 · PMID:8789747 · W2046440628
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This study investigated the effects of triptorelin and gestrinone, both individually and in combination, on experimental endometriosis in rats.

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Abstract

ObjectivesTo evaluate the effects of triptoreline, gestrinone, and both, on experimental endometriosis in rats.Study designExperimental endometriosis was surgically induced in 225 Wistar rats. Of these, 202 rats showed at least one grown implant, 22 of which composed the control group, while 180 were treated with triptoreline, gestrinone, or both, for 28 days. The implants were evaluated again after 25 days.ResultsThere were no changes in size in the control group. About 73% of the implants treated with triptoreline showed a high reduction (> 50%), vs. 51% with gestrinone (P < 0.0005) and 65% with both (P < 0.005). Triptoreline caused macroscopic resolution in 40% of the implants vs. 31% for gestrinone (not significant) and 26% for both substances (P < 0.05). In the triptoreline group, the mean size of the implants decreased by 65% between the 25th and 28th days, 58% between the 29th and the 35th, and 39% after the 36th day. This reduction was 51%, 36%, and 33%, respectively, in gestrinone group.ConclusionsTriptoreline was more effective than gestrinone, but perhaps not in the long run. Their association did not improve the results.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gestrinone Triptorelin Pamoate Animals Drug Therapy, Combination Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gestrinone Gestrinone Rats Rats, Wistar Triptorelin Pamoate Triptorelin Pamoate

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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