Telocytes in Inflammatory Gynaecologic Diseases and Infertility

Women suffered with inflammatory gynecologic diseases, such as endometriosis (EMs) and acute salpingitis (AS) often complained of sub- or infertility, even in those women without obvious macroscopic anatomical pelvic abnormalities also have unexplained infertility. Generally, besides the well-known impairment of classically described oviduct cells caused by inflammatory diseases, such as the ciliated cells, fibroblasts and myofibroblasts, the involvement of the newly identified telocytes (TCs) in disease-affected oviduct tissues and potential pathophysiological roles in fertility problems remain unknown. In this chapter, TCs was investigated in rat model of EMs- and AS-affected oviduct tissues. Results showed inflammation and ischaemia-induced extensive ultrastructural damages of TCs both in cellular body and prolongations, with obvious TCs loss and interstitial fibrotic remodelling. Such in vivo pathological alterations might contribute to structural and functional abnormalities of oviduct tissue and potentially engaged in sub- or infertility. And especially, TCs connected to various activated immunocytes in both normal and diseased tissues, thus might participate in local immunoregulation (either repression or activation) and serve a possible explanation for immune-mediated pregnancy failure. Then, in vitro cell co-culture study showed that uterine TC conditioned media (TCM) can activate mouse peritoneal macrophages and subsequently trigger its cytokine secretion, thus providepreliminary evidence that, TCs are not simply innocent bystanders, but are instead potential functional players in local immunoregulatory and immunosurveillance. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Near-infrared low-level laser stimulation of telocytes from human myometrium. Lasers Med Sci. 2014;29(6):1867–74. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2016 Springer Science+Business Media Singapore About this chapter Cite this chapter Yang, XJ. (2016). Telocytes in Inflammatory Gynaecologic Diseases and Infertility. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_18 Download citation DOI: https://doi.org/10.1007/978-981-10-1061-3_18 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-10-1060-6 Online ISBN: 978-981-10-1061-3 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

- Uterine telocytes - Interstitial cells - Stromal cells - Endometriosis - Pelvic inflammatory disease - Acute salpingitis (AS) - Inflammation - Inflammatory factors - Infertility - Fertility disorder - Tubal ectopic pregnancy - Tubal factor infertility - Rat model - Oviduct - Fibrosis - Immunoregulation - Immune response - Macrophage activation - Cytokines - Enzyme