Vascular endothelial growth factor expression up-regulated by endometrial ischemia in secretory phase plays an important role in endometriosis
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Endometrial ischemia during the secretory phase up-regulates vascular endothelial growth factor expression, which is important in the development of endometriosis.
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Abstract
Primary human endometrial cells were exposed to hypoxia preconditioning (HPC), HPC-hypoxia, and hypoxia conditions, and then endometrial tissue treated with ischemia preconditioning (IPC) was transplanted onto the chick embryo chorioallantoic membrane to investigate the role of slight ischemia of endometrium in the pathologic process of endometriosis. IPC up-regulated vascular endothelial growth factor expression and decreased apoptosis of endometrial cells, thus facilitating the endometrial fragments' ectopic implantation.
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Cited by (10)
- The Performance of the Uterine Artery Resistance Index following Stimulation of the Cervix in the Diagnosis of Endometriosis: A Prospective Study 2022
- Vascularization of endometrial tissue in abdominal cavity – the most important link in the pathogenesis of endometriosis or its vulnerable spot in terms of treatment? (review of literature) 2019
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis 2018
- Shaofu Zhuyu Decoction Regresses Endometriotic Lesions in a Rat Model 2018
- Telocytes in Inflammatory Gynaecologic Diseases and Infertility 2016
- Comprehensive study of angiogenic factors in women with endometriosis compared to women without endometriosis 2016
- Diagnosis of Endometriosis 2015
- Inflammation and Cytokines in Endometriosis 2014
- Telocytes damage in endometriosis‐affected rat oviduct and potential impact on fertility 2014
- Endometriosis, a disease of the macrophage 2013
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:16:42.478857+00:00
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