Silymarin amplifies apoptosis in ectopic endometrial tissue in rats with endometriosis; implication on growth factor GDNF, ERK1/2 and Bcl-6b expression

Elaheh Nahari, Nahari E, Mazdak Razi, Razi M
Acta histochemica · 2018 · vol. 120(8) , pp. 757–767 · doi:10.1016/j.acthis.2018.08.003 · PMID:30195499 · W2890234455
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Silymarin treatment of rats with endometriosis reduced ectopic endometrial tissue growth by increasing apoptosis and altering the expression of GDNF, ERK1/2, and Bcl-6b.

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Abstract

The present prospective study was done to evaluate the effect of silymarin (SMN) on endometriotic-like legions establishment and growth in experimentally-induced endometriosis. For this purpose, the experimental endometriosis was induced in 12 rats and then the animals subdivided into endometriosis-sole and SMN (50 mg kg-1, orally)+endometriosis groups. Following 28 days, the legions establishment, size, Glial cell line-derived neurotrophic factor (GDNF), gfrα1, B Cell Lymphoma 6 (Bcl-6b), Bcl-2, extracellular regulator kinase (ERK1/2) expression ratios, angiogenesis, the apoptosis and fibrosis indices were investigated. The SMN significantly (P < 0.05) decreased the enometriotic-like legions establishment and size, decreased mRNA levels of GDNF, gfrα1, Bcl-6b and Bcl-2 and remarkably diminished GDNF, gfrα1, Bcl-6b and Bcl-2-positive cells distribution/mm2 of tissue versus endometriosis-sole group. The SMN + endometriosis group exhibited a significant (P < 0.05) enhancement in ERK1/2 expression and represented diminished vascularized area and increased apoptosis and fibrosis indices, as well. In conclusion, the SMN by down-regulating GDNF and its receptor gfrα1 expression inhibits GDNF-gfrα1 complex generation and consequently suppresses Bcl-6b expression. Moreover, the SMN by enhancing the ERK1/2 expression and by suppressing the Bcl-2 expression promotes the apoptosis pathway. Finally, the SMN by down-regulating the angiogenesis ratio accelerates apoptosis and consequently induces severe fibrosis in endometriotic-like legions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glial Cell Line-Derived Neurotrophic Factor MAP Kinase Signaling System Proto-Oncogene Proteins c-bcl-6 Silymarin Animals Apoptosis Apoptosis Endometriosis Female Glial Cell Line-Derived Neurotrophic Factor Immunohistochemistry MAP Kinase Signaling System Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-bcl-6 Rats Real-Time Polymerase Chain Reaction Silymarin Up-Regulation

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