Application of the nuclear factor-κB inhibitor pyrrolidine dithiocarbamate for the treatment of endometriosis: an in vitro study
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This in vitro study investigated the potential of the nuclear factor-κB inhibitor pyrrolidine dithiocarbamate for treating endometriosis.
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Abstract
This study demonstrated that pyrrolidine dithiocarbamate (PDTC), a potent nuclear factor-κB inhibitor, showed stronger inhibitory effects on nuclear factor-κB activation in endometriotic stromal cells than in normal endometrial stromal cells as determined by electrophoretic mobility shift assay and Western blot analysis. Pretreatment of endometriotic stromal cells with PDTC attenuated tumor necrosis factor-α-induced expressions of CD44s, matrix metalloproteinase-9, and vascular endothelial growth factor whereas reversed tumor necrosis factor-α-reduced expressions of tissue inhibitor of metalloproteinase-1 revealed by reverse transcriptase polymerase chain reaction and Western blot analysis, suggesting that PDTC may represent a novel therapeutic strategy for treatment of endometriosis.
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Cited by (15)
- A Comprehensive Review of the Efficacy and Safety of Dopamine Agonists for Women with Endometriosis-associated Infertility from Inception to July 31, 2022 2023
- Medical treatments of endometriosis: a review 2022
- An Update on the Multifaceted Role of NF-kappaB in Endometriosis 2022
- Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review 2021
- MicroRNA‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway 2020
- Investigational drugs for the treatment of endometriosis, an update on recent developments 2018
- Silymarin amplifies apoptosis in ectopic endometrial tissue in rats with endometriosis; implication on growth factor GDNF, ERK1/2 and Bcl-6b expression 2018
- Current and emerging treatment options for endometriosis 2018
- Wenshen Xiaozheng Tang induces apoptosis and inhibits migration of ectopic endometriotic stromal cells 2016
- Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics 2016
- An Update on Pathophysiology and Medical Management of Endometriosis 2016
- An overview of early drug development for endometriosis 2015
- Potential New Drugs for Endometriosis: Experimental Evidence 2014
- Comparison of efficacy of bromocriptine and cabergoline to GnRH agonist in a rat endometriosis model 2014
- MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK /NF- B pathway and reduced interleukin-8 expression 2011
Source provenance
- europepmc
- last seen: 2026-07-30T06:25:42.655704+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:17:07.008521+00:00
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