Application of the nuclear factor-κB inhibitor pyrrolidine dithiocarbamate for the treatment of endometriosis: an in vitro study

Jing-jing Zhang, Zhang JJ, Jingjing Zhang, Zhi-ming Xu, Xu ZM, Zhiming Xu, Hongying Dai, Hong-ying Dai, Dai HY, Ji XQ, Xin-qiang Ji, Xinqiang Ji, Duan YY, Yu-ying Duan, Yuying Duan, Chunmei Zhang, Chun-mei Zhang, Zhang CM, Qin DY, Dongyan Qin, Dong-yan Qin
Fertility and sterility · 2010 · vol. 94(7) , pp. 2942–2944 · doi:10.1016/j.fertnstert.2010.05.009 · PMID:20561612 · W2018791459
Lab / animal OA: bronze CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This in vitro study investigated the potential of the nuclear factor-κB inhibitor pyrrolidine dithiocarbamate for treating endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study demonstrated that pyrrolidine dithiocarbamate (PDTC), a potent nuclear factor-κB inhibitor, showed stronger inhibitory effects on nuclear factor-κB activation in endometriotic stromal cells than in normal endometrial stromal cells as determined by electrophoretic mobility shift assay and Western blot analysis. Pretreatment of endometriotic stromal cells with PDTC attenuated tumor necrosis factor-α-induced expressions of CD44s, matrix metalloproteinase-9, and vascular endothelial growth factor whereas reversed tumor necrosis factor-α-reduced expressions of tissue inhibitor of metalloproteinase-1 revealed by reverse transcriptase polymerase chain reaction and Western blot analysis, suggesting that PDTC may represent a novel therapeutic strategy for treatment of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis NF-kappa B Peritoneal Diseases Pyrrolidines Thiocarbamates Antioxidants Antioxidants Antioxidants Antioxidants Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Drug Evaluation, Preclinical Drug Evaluation, Preclinical Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (11)

Cited by (15)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:07:39.929932+00:00
License: CC0 · commercial use OK