EXPERIMENTAL MODEL OF ENDOMETRIOSIS IN RATS

A Barbe, A. Berbets, И. С. Давыденко, О. M. Yuzko
In: Clinical & experimental pathology · 2019 · vol. 18(3) · doi:10.24061/1727-4338.xviii.3.69.2019.1 · W2984345322
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An experimental model of endometriosis was developed in rats, demonstrating viable and functionally active ectopic endometrium suitable for further research.

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The paper aimed to develop and determine the effectiveness of an experimental rat model of endometriosis in virgin, nulliparous adult female rats (23 Wistar females, 14–17 weeks old, 170–200 g). Using approved animal-bioethics procedures, the authors developed and adapted a model for clinical experimental studies and assessed whether ectopic endometrial tissue became viable and functionally active. They report that the ectopic endometrium in the model was viable and showed functional activity, supporting the model’s validity and suitability for further research. This paper is centrally about endometriosis — it focuses on developing and validating an experimental endometriosis model in rats.

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Abstract

An experimental model of endometriosis on white mature rats has been developed andadapted for clinical experimental studies.Objective. Development and determination of the effectiveness of the experimental modelof endometriosis on white female rats.All manipulations with animals were performed in accordance with the recommendationsof the UNESCO Intergovernmental Committee on Bioethics (IGBC).Material and methods. The experiment involved 23 adult non-linear non-linear whiteRattus Norvegicus Wistar female rats weighing 170-200 g, which had not yet given birthat the age of 14-17 weeks.Conclusions. Studies have shown the viability and functional activity of the ectopicendometrium experimental model which indicates its validity and the possibility of use infurther research.
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ЕКСПЕРИМЕНТАЛЬНА МОДЕЛЬ ЕНДОМЕТРІОЗУ НА ЩУРАХ DOI: https://doi.org/10.24061/1727-4338.XVIII.3.69.2019.1Ключові слова: ендометріоз, експериментальна модельАнотація Мета роботи - розроблення та визначення ефективності експериментальної моделіендометріозу на білих самках щурів. Матеріал і методи. В експерименті взяли участь 23 статевозрілі нелінійні білі щури Rattus Norvegicus Wistar жіночої статі масою 170-200 г, які ще не народжували, віком 14-17 тижнів. Усі маніпуляції з тваринами виконано відповідно до рекомендацій Міжурядового комітету з біоетики UNESCO (IGBC). Результати. Розроблено та адаптовано для клінічних експериментальних досліджень експериментальну модель ендометріозу на білих статевозрілих щурах. Висновки. Проведені дослідження засвідчують про життєздатність та функціональну активність ектопічного ендометрію експериментальної моделі, що вказує на її валідність та можливість використання під час подальших досліджень. Посилання 1.Giudice LC, Kao LC. Endometriosis. Lancet. 2004; 364 (9447):1789-99. doi: 10.1016/S0140-6736(04)17403-5 2.Lapp T. ACOG issues recommendations for the management of endometriosis. American College of Obstetricians and Gynecologists. Am Fam Physician. 2000;62(6):1431. 3.Rice VM. Conventional medical therapies for endometriosis. Ann N Y Acad Sci. 2002;955:343-52. doi: 10.1111/j.1749-66 32.2002.tb02795.x 4.Vernon MW, Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertil Steril. 1985;44(5):684-94. doi: 10.1016/S0015-0282(16)48988-0 5.Rajkumar K, Schott PW, Simpson CW. The rat as an animal model for endometriosis to examine recurrence of ectopic endometrial tissue after regression. Fertil Steril. 1990;53(5):921-5. doi: 10.1016/s0015-0282(16)53532-8 6.Rossi G, Somigliana E, Moschetta M, Santorsola R, Cozzolino S, Filardo P, et al. Dynamic aspects of endometriosis in a mouse model through analysis of implantation and progression. Arch Gynecol Obstet. 2000;263(3):102-7. doi: 10.1007/s004040050005 7.Shor E, Baracat EC, Simoes MJ, de Freitas V, Giannotti Filho O, de Lima GR. Effects of conjugated estrogens and progestogen in surgically induced endometriosis in oophorectomized rats. Clin Exp Obstet Gynecol. 1999;26(3-4):158-61. 8.Fang Z, Yang S, Lydon JP, DeMayo F, Tamura M, Gurates B, et al. Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis. Fertil Steril. 2004;82(3):673-8. doi: 10. 1016/j.fertnstert.2004.01.048 9.Cummings AM, Metcalf JL. Induction of endometriosis in mice: a new model sensitive to estrogen. Reprod Toxicol. 1995; 9(3):233-8. doi: 10.1016/0890-6238(95)00004-T 10.Katsuki Y, Takano Y, Futamura Y, Shibutani Y, Aoki D, Udagawa Y, et al. Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats. Eur J Endocrinol. 1998; 138(2):216-26. doi: 10.1530/eje.0.1380216 11.Somigliana E, Vigano P, Rossi G, Carinelli S, Vignali M, Panina-Bordignon P. Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis. Hum Reprod. 1999;14(12):2944-50. doi: 10.1093/ humrep/14.12.2944 12.Hirata T, Osuga Y, Yoshino O, Hirota Y, Harada M, Takemura Y, et al. Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein. Hum Reprod. 2005;20(8):2092-6. doi: 10. 1093/humrep/ dei012 13.Yao Z, Shen X, Capodanno I, Donnelly M, Fenyk-Melody J, Hausmann J. Validation of rat endometriosis model by using raloxifene as a positive control for the evaluation of novel SERM compounds. J Invest Surg. 2005;18(4):177-83. doi: 10.1080/0894 1930591004412 14.Golan A, Winston RM, Dragenio R. Experimental endometriosis: a microsurgical animal model in rats. Isr J Med Sci. 1984; 20(11):1094-6. 15.Nisolle M, Casanas-Roux F, Anaf V, Mine JM, Donnez J. Morphometric study of the stromal vascularization in peritoneal endometriosis. Fertil Steril. 1993;59(3):681-4. doi: 10.1016/ S0015-0282(16)55823-3 16.Elgamal AD, Othman E-ER, Agmed FS. Ultrastructural Features of Eutopic Endometrium in a Rat Model of Endometriosis. J Microsc Ultrastruct. 2016;4(1):20-7. doi: 10.1016/ j.jmau.2015.10.002 17.Rezende CAL, Silva AL, Junior JLS, Gobbi H, Martins MMF. Experimental model for endometriosis. Comparative histological study between the ectopic and eutopic endometrium. Acta Cir Bras. 1997;12(4):226-30. doi: 10.1590/S0102-86501997000400003 18.Nogueira Neto J, Torres OJ, Coelho TM, Nunes JN Jr, Aguiar GC, Costa LK. Evaluation of the macroscopic growth degree of experimental endometriosis in rats. Acta Cir Bras. 2007;22(Suppl 1):8-11. doi: 10.1590/S0102-86502007000700003 19.do Amaral VF, Dal Lago EA, Kondo W, Souza LC, Francisco JC. Development of an experimental model of endometriosis in rats. Rev Col Bras Cir. 2009;36(3):250-5. doi: 10.1590/S0100- 69912009000300012 ##submission.downloads## Опубліковано Номер Розділ Ліцензія Авторське право (c) 2019 A. M. Barbe, A. М. Berbets, I. S. Davydenko, O. M. Yuzko Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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