Dynamic aspects of endometriosis in a mouse model through analysis of implantation and progression

Gabriele Rossi, G Rossi, Edgardo Somigliana, E Somigliana, M Moschetta, Roberta Santorsola, R Santorsola, S Cozzolino, Sabrina Cozzolino, Paola Filardo, P Filardo, A Salmaso, Anita Salmaso, Beatrice Zingrillo, B Zingrillo
Archives of gynecology and obstetrics · 2000 · vol. 263(3) , pp. 102–107 · doi:10.1007/s004040050005 · PMID:10763836 · W2024088889
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriotic lesions in mice initially decreased then significantly increased in size over time, with progression dependent on ovarian integrity but not implantation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper established a dynamic mouse model of endometriosis by surgically transplanting autologous endometrium into 30 normal immunocompetent mice and then assessing lesion initiation and growth at serial time points using histology and caliper-based lesion area measurements. Lesions were confirmed at 3 weeks and showed an initial decrease in area followed by a significant increase over the subsequent 4 weeks, indicating that implantation and progression represent different stages in disease development, with progression depending on intact ovaries (bilateral ovariectomy at the second laparotomy reduced lesion surface, unlike ovariectomy at the time of transplantation). In estrogen-supplemented mice, lesion growth appeared less evident, with only a slight non-significant increase in size. This paper is centrally about endometriosis — it characterizes implantation versus progression dynamics in a mouse model and evaluates how ovaries and estrogen modulation affect lesion development.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Peritoneal Diseases Animals Disease Progression Endometriosis Endometrium Endometrium Female Humans Mice Mice, Inbred Strains Peritoneal Diseases Peritoneum Peritoneum Transplantation, Autologous

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